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The multifaceted roles of deubiquitinating enzymes (DUBs) in pancreatic ductal adenocarcinoma [PDF]
Cell Death and DiseasePancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal gastrointestinal cancers worldwide. The diagnostic and treatment limitations have resulted in great challenges in improving the survival of patients with PDAC.
Min Zhou +6 more
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The Potential Role of Deubiquitinating Enzymes (DUBs) in Male Fertility [PDF]
BiomoleculesUbiquitination dynamically regulates critical cellular processes, including cell cycle progression, apoptosis, DNA repair, and chromatin remodeling. Deubiquitinating enzymes (DUBs) negatively regulate protein ubiquitination and are equally important for ...
Jung Min Kim
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Research progress of deubiquitinating enzymes in cerebral ischemia-reperfusion injury [PDF]
Frontiers in Aging NeuroscienceCerebral ischemia-reperfusion injury (CIRI) is a critical pathological process driving neurological deterioration following ischemic stroke, involving multifaceted mechanisms such as inflammatory cascades, oxidative stress, and programmed cell death (PCD)
XiaoHong Qin +6 more
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The Role of Deubiquitinases in Virus Replication and Host Innate Immune Response
Frontiers in Microbiology, 2022 As a critical post-translational modification, ubiquitination is known to affect almost all the cellular processes including immunity, signaling pathways, cell death, cancer development, and viral infection by controlling protein stability ...
Qinglin Zhang +3 more
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Regulation of the transforming growth factor β pathway by reversible ubiquitylation [PDF]
Open Biology, 2012 The transforming growth factor β (TGFβ) signalling pathway plays a central role during embryonic development and in adult tissue homeostasis. It regulates gene transcription through a signalling cascade from cell surface receptors to intracellular SMAD ...
Mazin A. Al-Salihi +2 more
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Post-Translational Modifications of Deubiquitinating Enzymes: Expanding the Ubiquitin Code
Frontiers in Pharmacology, 2021 Post-translational modifications such as ubiquitination play important regulatory roles in several biological processes in eukaryotes. This process could be reversed by deubiquitinating enzymes (DUBs), which remove conjugated ubiquitin molecules from ...
Yanfeng Wang, Feng Wang
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DUBing Primary Tumors of the Central Nervous System: Regulatory Roles of Deubiquitinases
Biomolecules, 2023 The ubiquitin proteasome system (UPS) utilizes an orchestrated enzymatic cascade of E1, E2, and E3 ligases to add single or multiple ubiquitin-like molecules as post-translational modification (PTM) to proteins. Ubiquitination can alter protein functions
Thomas Klonisch +3 more
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Targeting deubiquitinases for cancer therapy
Clinical and Translational Discovery, 2023 The ubiquitin‐proteasome system assumes a critical role in numerous cellular processes, and among its components, deubiquitinases (DUBs) have emerged as essential regulators.
Qian Xue +3 more
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Deubiquitylation of deubiquitylases [PDF]
Open Biology, 2017 Deubiquitylating enzymes (DUBs) reverse the ubiquitylation of target proteins, thereby regulating diverse cellular functions. In contrast to the plethora of research being conducted on the ability of DUBs to counter the degradation of cellular proteins ...
Saba Haq, Suresh Ramakrishna
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Biomedicines, 2020 Protein ubiquitinations play pivotal roles in many cellular processes, including homeostasis, responses to various stimulations, and progression of diseases.
Hirotaka Takahashi +8 more
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