Results 21 to 30 of about 12,468 (237)
, 1880 Porträt von Jakob Dubs (1822-1879), Bundesrat und Präsident des Hülfsvereins für schweizerische Wehrmänner und deren FamilienF.B.Faksimilierte Unterschrift Dubs' am unteren ...
F.B
core +1 more source
Emergent Spin Supersolids in Frustrated Quantum Materials
Advanced Materials, EarlyView.This review highlights developments in the study of spin super‐solids in frustrated quantum materials. Advanced experimental characterizations and computational studies enable a comprehensive understanding of the driving mechanisms of spin super‐solidity in various layered transition‐metal compounds, bridging materials, experiments, and theory aspects.
Yixuan Huang +2 more
wiley +1 more source
Advanced Materials, EarlyView.Using 640 curated electrolyte formulations, we apply data‐driven analysis to reveal how molecular features govern coulombic efficiency (CE) in lithium metal batteries. Fluorine content correlates positively with CE, while oxygen, carbon, and higher boiling points correlate negatively.
Minh Van Duong +6 more
wiley +1 more source
Advanced Science, EarlyView.Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li +8 more
wiley +1 more source
Advanced Science, EarlyView.USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen +7 more
wiley +1 more source
Putative SGTA interacting DUBs identified by mass spectrometry.
, 2022 Pull-down experiments were performed as described in Materials and Methods. The beads were then analysed for bound proteins by mass spectrometry as detailed in the materials and methods.
Jake Hill (13162865) +1 more
core +1 more source
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Phylogram representation of DUBs.
, 2013 Indicated with arrows are DUB homologs that were cloned and expressed by in vitro transcription/translation (IVT). Red arrows depict DUBs that bound to neither probe (UbVME, ISG15VS, or SUMO1VS), whereas black arrows indicate DUBs that formed covalent ...
Daniël Blom (32523) +5 more
core +1 more source
A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers
Advanced Science, EarlyView.Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels +2 more
wiley +1 more source
, 2012 A) Shown are human DUBs categorized into five subclasses based on homology at the catalytic domain [1], [3]. UCH: Ubiquitin C-terminal Hydrolases, USP: Ubiquitin-Specific Proteases, MJD: Machado-Joseph Disease Proteases, OTU: Otubain proteases, JAMM ...
Michael J. Sheedlo (143431) +6 more
core +1 more source