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DUBs, Hypoxia, and Cancer [PDF]
Trends in Cancer, 2019 Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer. Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be opposed by deubiquitinases (DUBs), which have emerged as promising drug targets.
Thomas Kietzmann, Daniela Mennerich
exaly +6 more sources
Journal of Cell Science, 2009 The discovery of protein ubiquitylation three decades ago was the beginning of our understanding of a new mechanism by which proteins are marked for assembly into macromolecular complexes or movement between cellular compartments.
Keith D Wilkinson
exaly +3 more sources
DUBs, New Members in the Hypoxia Signaling clUb
Frontiers in Oncology, 2016 Cellular protein homeostasis is tightly regulated by ubiquitination. Responsible for target protein ubiquitination is a class of enzymes, the so-called ubiquitin (Ub) E3-ligases.
Edurne Berra
exaly +2 more sources
Pseudo-DUBs as allosteric activators and molecular scaffolds of protein complexes [PDF]
Biochemical Society Transactions, 2018 The ubiquitin (Ub) proteasome system and Ub signalling networks are crucial to cell biology and disease development. Deubiquitylases (DUBs) control cell signalling by removing mono-Ub and polyubiquitin chains from substrates. DUBs take part in almost all
Miriam Walden +2 more
exaly +2 more sources
, 2020 "The real argument is that we are talking about children. I feel very emotionally attached to the Czech Republic and I feel sad that they don't want to do anything for child refugees. It is humanity.
Culik, Jan, Dubs, Lord Alf
core +7 more sources
Deubiquitinases (DUBs) and DUB inhibitors: a patent review [PDF]
Expert Opinion on Therapeutic Patents, 2015 Deubiquitinating-enzymes (DUBs) are key components of the ubiquitin-proteasome system (UPS). The fundamental role of DUBs is specific removal of ubiquitin from substrates. DUBs contribute to activation/deactivation, recycling and localization of numerous regulatory proteins, and thus play major roles in diverse cellular processes.
Pershang, Farshi +6 more
openaire +2 more sources
Netflix Disrupting Dubbing:English Dubs and British Accents [PDF]
, 2021 In 2017, English dubbing entered the mainstream on the initiative of the subscription video-on-demand service (SVoD) Netflix. Recent English dubs have taken advantage of the largely convention-free English dubbing industry and, in 2019, dubs outsourced ...
Hayes, Lydia
core +1 more source
(Main)streaming English Dubs [PDF]
, 2022 With ‘original’ content from a growing diversity of languages, Netflix has become a playground for audiovisual translation. Given that Netflix outsources its localisation, it has been able to rely on practitioners in consolidated industries to create ...
Hayes, Lydia +1 more
core +1 more source