Results 21 to 30 of about 11,793 (291)

Schule und New Public Management

Beiträge zur Lehrerinnen- und Lehrerbildung, 1996
Die Redaktion der ''Beiträge zur Lehrerbildung" hat mich um eine Stellungnahme zum Beitrag von Professor Ulrich Herrmann über "Die Schule - eine Herausforderung für das New Public Management (NPM)" gebeten.
Rolf Dubs
doaj   +1 more source

Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses

Frontiers in Immunology, 2021
Hijacking host ubiquitin pathways is essential for the replication of diverse viruses. However, the role of deubiquitinating enzymes (DUBs) in the interplay between viruses and the host is poorly characterized. Here, we demonstrate that specific DUBs are
Wenying Gao, Yajuan Rui, Guangquan Li, Chenyang Zhai, Jiaming Su, Han Liu, Wenwen Zheng, Baisong Zheng, Wenyan Zhang, Yongjun Yang, Shucheng Hua, Xiaofang Yu, Xiaofang Yu   +12 more
doaj   +1 more source

Dubbing

, 2022
This entry is concerned with dubbing as a modality of audiovisual translation. Here, our main objective is to present a thorough analysis of dubbing, taking into account every aspect that influences the entire process, including historical, professional, technical and contextual elements.
openaire   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

The Roles of Deubiquitination in Age-related Diseases [PDF]

Zhongguo quanke yixue
Deubiquitination, mediated by deubiquitinating enzymes (DUBs), represents a crucial class of post-translational protein modifications. Its primary mechanism involves in the interaction of DUBs with ubiquitinated target proteins, whereby the DUBs cleave ...
XU Linhui, LI Pengfei, WU Miaomiao, KANG Lihua, JI Min, YU Ying, GUAN Huaijin
doaj   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

RNA-seq provides insights into potato deubiquitinase responses to drought stress in seedling stage

Frontiers in Plant Science, 2023
Ubiquitination is a specific protein degradation and reversible post-translational modification process that can be reversed by deubiquitinase (DUBs).
Xun Tang, Xun Tang, Fujun Sun, Ning Zhang, Ning Zhang, Birendra Bahadur Rana, Raju Kharel, Pan Luo, Huaijun Si, Huaijun Si   +9 more
doaj   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Deubiquitinating enzymes: potential regulators of the tumor microenvironment and implications for immune evasion

Cell Communication and Signaling
Ubiquitination and deubiquitination are important forms of posttranslational modification that govern protein homeostasis. Deubiquitinating enzymes (DUBs), a protein superfamily consisting of more than 100 members, deconjugate ubiquitin chains from ...
Sheng-Kai Hsu, Chon-Kit Chou, I-Ling Lin, Wen-Tsan Chang, I-Ying Kuo, Chien-Chih Chiu   +5 more
doaj   +1 more source

Predicting Atomic Charges in MOFs by Topological Charge Equilibration

Advanced Functional Materials, EarlyView.
An atomic charge prediction method is presented that is able to accurately reproduce ab‐initio‐derived reference charges for a large number of metal–organic frameworks. Based on a topological charge equilibration scheme, static charges that fulfill overall neutrality are quickly generated.
Babak Farhadi Jahromi, Sumukh Shankar Sharadaprasad, Rochus Schmid   +2 more
wiley   +1 more source