Results 111 to 120 of about 30,575 (221)

TRF2 Recovers Ischemic Postconditioning Cardioprotection in Aged Myocardiocytes by Regulating CSNK2A2 Localization and FUNDC1 Dephosphorylation

Aging Cell, Volume 25, Issue 8, August 2026.
Myocardial expression of telomeric repeat‐binding factor 2 (TRF2) was reduced in aged male mice and further downregulated following ischemic postconditioning (I/Post). Mechanistically, TRF2 confers cardioprotection by interacting with casein kinase 2 alpha 2 polypeptide (CSNK2A2) to modulate FUN14 domain‐containing protein 1 (FUNDC1) dephosphorylation,
Xuan Zhang, Ji Ma, Ruichen Shu, Yuan Li, Ying Zheng, Yiqing Yin   +5 more
wiley   +1 more source

Empowering Clinical Development With Disease Progression Modeling: Recommendations From the Clinical Trials Transformation Initiative

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Evaluating the benefit–risk profile of a medical product requires comprehensive evidence that integrates information across development stages. Technological advances and broader use of real‐world data are enabling innovative quantitative paradigms characterized by greater efficiency, patient centricity, and sustainability.
Lindsay S. Kehoe, Shu Chin Ma, Jiang Liu, Qi Liu, Herbert Pang, Bruce Burnett, Reem Yunis, Karthik Venkatakrishnan   +7 more
wiley   +1 more source

Embolismo graso en un niño con distrofia muscular de duchenne y fractura bilateral de fémur. Una rara asociación.

Revista de la Facultad de Medicina, 2007
Las fracturas de fémur en pacientes que sufren de distrofia muscular de Duchenne (DMD) son frecuentes, con una incidencia entre 15-44 por ciento. El embolismo graso se presenta en fracturas de huesos largos generalmente asociado a trauma de alta energía ...
Enrique Vergara Amador, Fernando Galván Villamarín, Marcela Piña Quintero   +2 more
doaj  

Screening for brain‐related comorbidities in Duchenne muscular dystrophy: Construction, reliability, and validity of the BIND screener

Developmental Medicine &Child Neurology, Volume 68, Issue 8, Page 1080-1096, August 2026.
The Brain Involvement iN Dystrophinopathies (BIND) screener is an 18‐item questionnaire with strong reliability and validity for identifying potential brain‐related comorbidities in Duchenne muscular dystrophy. It allows rapid, cross‐age and cross‐country screening for both clinical and research purposes, demonstrating good sensitivity and specificity.
Ruben Miranda, Pien M. M. Weerkamp, Anna Kolesnik, Chloe Geagan, Daniela Chieffo, Mariana Suárez‐Bagnasco, David Skuse, Elizabeth Vroom, Erik H. Niks, John Vissing, Isabelle Desguerre, Volker Straub, Francesco Muntoni, Eugenio Mercuri, Jos G. M. Hendriksen, on behalf of BIND Consortium, Nathalie Angeard, Dimitrios Athanasiou, Suzie‐Ann Bakker, Nathalie Boddaert, Ellie Drummond, Chloe Durrlemann, Fernanda Fortunato, Luis Miguel García‐Moreno, Mattia Gervasi, Rosanne Govaart, Irina Guliaeva, Catherine Hankinson, Leslie Hemar, Rebecca Hendel, Hermien Kan, Leevi Kerkela, Gregory Landon, Monika Malinova, William Mandy, Federica Moriconi, Monia Pellizzari, Sarah Poncet, Elvina Sakellariou, Sergiu Siminiuc, Anna Würgler Slipsager, Lily Smythe, Pietro Spitali, Mads Peter Godtfeldt Stemmerik, Asmus Vogel, Jeanne Wolstencroft, Camilla Zanetti   +46 more
wiley   +1 more source

Feasibility of an Adapted Participatory Group Programme for Caregivers of Children With Complex Neurodisability in the United Kingdom: Results From the Encompass‐2 Study

Health Expectations, Volume 29, Issue 4, August 2026.
ABSTRACT Introduction ‘Encompass’ is a participatory group‐based intervention originating from low‐ and middle‐income countries, co‐developed with parents and professionals to enhance the well‐being, health literacy and empowerment of caregivers of young children with complex neurodisability.
Kirsten Prest, Kirsten Barnicot, Catherine Hurt, Cally J. Tann, Michelle Heys, Angela Harden   +5 more
wiley   +1 more source

Bone health in adults with non‐ambulatory neuromuscular disorders: scoping review of risk factors, diagnosis and management

Internal Medicine Journal, Volume 56, Issue 8, Page 1283-1300, August 2026.
Abstract Background Non‐ambulatory adults have an increased risk of osteoporosis and fractures due to reduced weight‐bearing and diminished neuromuscular stimulation, resulting in substantial morbidity and mortality. Aims This scoping review aimed to systematically evaluate risk factors, diagnostic indicators and management strategies for optimising ...
Thomas Bailey, Carolyn Droste, John A. Eisman, Steven G. Faux, Arnagretta Hunter   +4 more
wiley   +1 more source

Prognostic Impact of Concomitant Genomic Alterations in FGFR2‐Positive Cholangiocarcinoma Treated With Pemigatinib

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background & Aims Anti‐FGFR therapies changed the treatment landscape for patients with previously treated, advanced, or metastatic cholangiocarcinoma (CCA) harbouring FGFR2 fusions/rearrangements. However, primary resistance to FGFR inhibitors remains a key challenge. In the present real‐world study, we aimed to evaluate the prognostic impact
Carolina Liguori, Riccardo Giampieri, Blandine Delaunay, Giada Pinterpe, Adelaide Mazzocca, Antoine Hollebecque, Jean Frederic Blanc, Mohamed Bouattour, Eric Assenat, Meher Ben Abdelghani, Matthieu Sarabi, Monica Niger, Caterina Vivaldi, Mario Mandalà, Andrea Palloni, Maria Bensi, Silvio Ken Garattini, David Tougeron, Pierre Combe, Massimiliano Salati, Margherita Rimini, Andrea Casadei‐Gardini, Chiara Alessandra Cella, Marco Tucci, Anna Diana, Elena Mori, Raffaella Longarini, Pascal Artru, Gael Roth, Ludovic Evesque, Agathe Vienne, Anthony Turpin, Sandrine Hiret, Vincent Bourgeois, Camille Herve, Rodolphe Paulon, Marion Stacoffe, David Malka, Matthieu Delaye, Julien Edeline, Astrid Lievre, Rosine Guimbaud, Rita Balsano, Nadim Fares, Rossana Berardi, Alessandro Parisi   +45 more
wiley   +1 more source

LKB1 Dysregulation in Duchenne Muscular Dystrophy Models: Disease Specificity and Epigenetic Control by HDAC Inhibitors

Annals of the New York Academy of Sciences, Volume 1562, Issue 1, August 2026.
Our study demonstrated that the LKB1–STRADα–MO25 complex was significantly downregulated in Duchenne muscular dystrophy (DMD) models, concurring with the disruption of mechano‐metabolic signaling. Treatment with the HDAC inhibitor, vorinostat, successfully restored LKB1 expression by suppressing specific repressor miRNAs.
Brigida Boccanegra, Lisamaura Tulimiero, Raffaella Quarta, Elena Conte, Simonetta Andrea Licandro, Alessandra Decio, Roberta Lenti, Alberto Ladisa, Giorgia Dinoi, Gaia Carbone, Letizia Claudione, Giulia Maria Camerino, Sabata Pierno, Paola Mantuano, Ornella Cappellari, Gianluca Fossati, Christian Steinkühler, Annamaria De Luca   +17 more
wiley   +1 more source

Altered Skeletal Muscle Phosphate Metabolism After Muscle Damage Is Associated With Elevated Effort Perception During Exercise in Humans

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 8, August 2026.
ABSTRACT It remains unclear why exercising damaged muscles is perceived as disproportionately more effortful. Given the known role of inorganic phosphate (Pi) in fatigue and afferent sensory signaling, we tested whether muscle damage disrupts phosphate metabolism and whether this is associated with heightened ratings of perceived exertion (RPE ...
Jamie Stewart McPhee, Aneurin James Kennerley, Jean‐Christophe Lagacé, James McStravick, Susan Pinner, Fabio Zambolin   +5 more
wiley   +1 more source

Cardiac MRI in cardiac dystrophinopathy: recommendations on imaging. [PDF]

Open Heart
McDiarmid A, Augustine D, Coats C, Myerson SG, Hughes M, Villa C, Soslow J, Kadhim K, Kerr A, Kuhwald L, Sado DM, Swoboda P, Turner C, Guglieri M, Bourke J, Members of the CMR focus group of DMD Care UK.   +15 more
europepmc   +1 more source