Results 151 to 160 of about 71,442 (257)

Hope and the Life Course: Results From a Longitudinal Study of 25,000 Adults

open access: yesHealth Economics, Volume 35, Issue 1, Page 90-101, January 2026.
ABSTRACT This paper reports the first large‐scale longitudinal links between one of the least known dimensions of wellbeing—hope—and long‐term outcomes in a range of life arenas. Hope has agentic properties which are relevant to people's future outcomes. Following 25,000 randomly sampled Australian adults over a period of 14 years from 2007 to 2021 (N >
Carol Graham, Redzo Mujcic
wiley   +1 more source

Psychometric evaluation of the PROMIS parent proxy mobility item bank for use in Duchenne muscular dystrophy [PDF]

open access: hybrid
Linda Lowes   +6 more
openalex   +1 more source

Obestatin Treatment Counteracts Muscle Wasting by Reactivation of Autophagy in Duchenne Muscular Dystrophy

open access: yesMedComm, Volume 7, Issue 1, January 2026.
Obestatin signaling reactivates autophagy by NEDD4‐L activation under DMD conditions. Tyrosine switch on NEDD4‐L activates autoubiquitination that serves as a scaffold to recruit USP10 to form a deubiquitination complex, which stabilizes VPS34 to promote autophagy by activation of the Beclin1 complex. In parallel, NEDD4‐L favors AMPK exposure to CaMKKß
Icía Santos‐Zas   +16 more
wiley   +1 more source

Identification and Functional Characterization of a Novel SEMA3A Exon Deletion Variant in Kallmann Syndrome

open access: yesMolecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
The study identified a novel SEMA3A exons 6–9 deletion variant in Kallmann syndrome that impairs GnRH neuronal migration and alters cell migration, gonad development, and synaptic pathways. The study expands mutation spectrum and offers mechanistic insights for clinical diagnosis of Kallmann syndrome.
Shaolian Zang   +4 more
wiley   +1 more source

Targeted Carrier Screening for Thalassemia, Hereditary Deafness, and Spinal Muscular Atrophy: A Feasible Approach for Preventing Birth Defects in China's Community Healthcare System

open access: yesMolecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
Current carrier screening primarily focuses on high detection rates and broad testing ranges. We approach the issue from the perspective of a community physician, evaluating the suitability of carrier screening based on factors such as cost, ease of report interpretation, and compliance issues.
Zhihui Wang   +6 more
wiley   +1 more source

Protein Target Highlights in CASP16: Insights From the Structure Providers

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 25-50, January 2026.
ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander   +34 more
wiley   +1 more source

Duchenne muscular dystrophy [PDF]

open access: bronze, 2019
Lenka Juříková   +2 more
openalex   +1 more source

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