Results 61 to 70 of about 73,992 (251)
Contrasting Experimentally Device-Manipulated and Device-Free Smiles. [PDF]
, 2019 Researchers in psychology have long been interested in not only studying smiles, but in examining the downstream effects of experimentally manipulated smiles.
Cross, Marie P +2 more
core
Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy [PDF]
, 2018 Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscle by ...
Díaz Manera, Jordi +6 more
core +1 more source
Annals of the Child Neurology Society, EarlyView.ABSTRACT Objective Pediatric neuropalliative medicine (PNPM) is a recently developed area of subspecialty neurology practice focused on supporting the complex emotional, psychological, and physical aspects of caring for a child with serious neurological disease.
Lauren Treat +2 more
wiley +1 more source
International Journal of Neonatal Screening, 2019 Duchenne muscular dystrophy (DMD/Duchenne) is a progressive X-linked disease and is the most common pediatric-onset form of muscular dystrophy, affecting approximately 1:5000 live male births. DNA testing for mutations in the dystrophin gene confirms the
Anne Timonen +11 more
doaj +1 more source
Nitric oxide regulates skeletal muscle fatigue, fiber type, microtubule organization, and mitochondrial ATP synthesis efficiency through cGMP-dependent mechanisms [PDF]
, 2016 Aim: Skeletal muscle nitric oxide–cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity.
Balke, Jordan E +8 more
core +1 more source
Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle
Developmental Dynamics, EarlyView.Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell +3 more
wiley +1 more source
Translational Exercise BiomedicineAs the Duchenne Muscular Dystrophy (DMD) is a progressive neuromuscular disorder frequently associated with cardiac dysfunction, this study aimed to evaluate the influence of beta-blocker therapy on cardiac autonomic modulation in adolescents with DMD by
Silva-Magalhães Talita Dias da +10 more
doaj +1 more source
CLINICAL CASE OF FAMILIAL DUCHENNE MYODYSTROPHY
Мать и дитя в Кузбассе, 2022 The article presents an analysis of a clinical case of the diagnosis of familial Duchenne myodystrophy in a newborn child confirmed in the neonatal period. The stages of diagnosis and their peculiarities are described.
Марина Афанасьевна Соколовская +2 more
doaj
Targeting PKCθ promotes satellite cell self-renewal [PDF]
, 2020 Skeletal muscle regeneration following injury depends on the ability of satellite cells (SCs) to proliferate, self-renew, and eventually differentiate. The factors that regulate the process of self-renewal are poorly understood. In this study we examined
Benedetti, Anna +4 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo +7 more
wiley +1 more source