Results 131 to 140 of about 73,251 (284)

Mini‐Catalytically Inactive Cas13X‐Derived RNA Base Editing of β‐Catenin Attenuates Pulmonary Damage in a Murine Acute Lung Injury Model

MedComm, Volume 7, Issue 4, April 2026.
AAV6.2FF‐delivered CARTEL (mini‐dCas13X‐mediated A‐to‐I editor) introduces c.121A>G editing in β‐catenin RNA of alveolar type II cells, leading to sustained Wnt/β‐catenin activation, robust AT2 proliferation, significant attenuation of LPS‐induced acute lung injury, and no excess off‐target edits or fibrotic toxicity for 4 weeks.
Wenyi Liu, Wanda Bi, Saiying Hou, Juan Du, Ling Zeng, Anqiang Zhang, Huacai Zhang, Dalin Wen, Qingli Cai, Chu Gao, Ping Lin, Min Wu, Li Li, Jianxin Jiang   +13 more
wiley   +1 more source

Aggravation of Cardiovascular and Respiratory Decline in Advanced Duchenne Muscular Dystrophy Complicated by Dilated Cardiomyopathy – Case Study and Review of Literature

Journal of Education, Health and Sport
Introduction: Duchenne muscular dystrophy is a genetic X-linked recessive disorder. This condition is characterized by progressive loss of muscle tissue. Thus, it results in deterioration and inability to perform basic motor skills such as independent
Iwona Welian-Polus, Bartosz Mazur, Michał Bielak, Magdalena Mazur, Elżbieta Rypulak, Wiktoria Wilanowska, Anna Greguła, Karol Stachyrak, Dawid Mika, Kamila Turek   +9 more
doaj   +1 more source

Carrier detection of duchenne and becker muscular dystrophy using muscle dystrophin immunohistochemistry [PDF]

, 1992
Acary Souza Bullé Oliveira, Alberto Alain Gabbai, Beny Schmidt, Beatriz Hitomi Kiyomoto, G. Camargo Lima, Carlo Minetti, Eduardo Bonilla   +6 more
openalex   +1 more source

The Role of Polyphenols in Regulating Skeletal Muscle Development and Homeostasis: Molecular Mechanisms and Potential Medical Applications

Molecular Nutrition &Food Research, Volume 70, Issue 8, 27 April 2026.
Graphical abstract describes the impact of polyphenols on signal transduction pathways involved in the development, differentiation and regeneration of muscle tissue. ABSTRACT A healthy lifestyle, characterized by moderate physical activity, appropriate caloric intake, and a diet rich in fruits and vegetables, contributes to maintaining overall health ...
Roberto Mattioli, Daniel Di Risola, Carmen Chiaradia, Ivan Dimauro, Luciana Mosca, Guglielmo Duranti, Roberta Ceci   +6 more
wiley   +1 more source

P3248Investigating dilated cardiomyopathy caused by dystrophin mutations using duchenne muscular dystrophy-patients induced pluripotent stem cell-derived cardiomyocytes [PDF]

, 2017
Binyamin Eisen, Ronen Ben Jehuda, Lucy N. Mekies, Yuval Shemer, Ashley J. Cuttitta, Lorenzo Monserrat, Mihaela Gherghiceanu, Michael Arad, Dov Freimark, Daniel E. Michele, Ofer Binah   +10 more
openalex   +1 more source

The Utility of Strain Echocardiography in the Diagnosis of Pediatric Myocarditis: A Systematic Review and Meta‐Analysis

Echocardiography, Volume 43, Issue 4, April 2026.
Strain echocardiographic assessment yields reduced LV‐GLS values across the pediatric myocarditis population. These remain abnormal irrespective of LVEF status. There is good concordance between strain echocardiography and CMR. Strain echocardiography is a useful diagnostic tool in suspected pediatric myocarditis. CMR, cardiac magnetic resonance; LVEF,
Krzysztof Macierzanka, Abhisekh Chatterjee, Ahmer Adnan, Hassan Marzook, Rafay Yousaf, Craig Laurence, Javier Gavela   +6 more
wiley   +1 more source

MYH11 variants in thoracic aortic aneurysm pathophysiology: From bench to bedside

European Journal of Clinical Investigation, Volume 56, Issue 4, April 2026.
Thoracic aortic aneurysms and dissections (TAAD) are often asymptomatic until rupture or dissection, which are associated with high mortality. Around 20% of cases of TAAD show familial segregation; some of these are linked to pathogenic variants in vascular smooth muscle cell contractile genes, like MYH11.
Aria Atash, Barend M. E. Mees, Maarten J. Cramer, Annette F. Baas, Leon J. Schurgers, Pieter A. Doevendans, Francesca Stillitano   +6 more
wiley   +1 more source

Multiomics Analysis of the mdx/mTR Mouse Model of Duchenne Muscular Dystrophy [PDF]

, 2019
Douglas W. Van Pelt, Yalda A. Kharaz, Dylan C. Sarver, Logan R. Eckhardt, Justin T. Dzierzawski, Nathaniel P. Disser, Alex N. Piacentini, Eithne Comerford, Brian McDonagh, Christopher L. Mendias   +9 more
openalex   +1 more source

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan, Ezgi Erbasan, Fulya Erendor, Salih Sanlioglu   +3 more
wiley   +1 more source

Cognitive Function in Duchenne Muscular Dystrophy Patients

Neurologijos seminarai
Duchenne muscular dystrophy is a rare, progressive, X-linked recessive disorder, characterized by impaired synthesis of the protein dystrophin. Motor symptoms in boys typically emerge within the first year of life, followed by progressive cardiac ...
Viktorija Urbanovič, Jurgita Grikinienė   +1 more
doaj   +1 more source