Beyond the Curve: The Muscle‐Specific Asymmetries of Adolescent Idiopathic Scoliosis
JOR SPINE, Volume 8, Issue 4, December 2025.Asymmetries in paraspinal muscle volume, intramuscular fat, and fat‐free muscle, observed across 11 vertebral levels, were greater in Adolescents with Idiopathic Scoliois (AIS) than in typically developing controls. Muscle asymmetries follow the shape of the scoliotic curve, typically with greater muscle volumes and intramuscular fat on the concave ...
Phoebe Duncombe +5 more
wiley +1 more source
Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP
JCI InsightSkeletal muscle wasting results from numerous pathological conditions affecting both the musculoskeletal and nervous systems. A unifying feature of these pathologies is the upregulation of members of the E3 ubiquitin ligase family, resulting in increased
Avnika A. Ruparelia +12 more
doaj +1 more source
MedComm, Volume 6, Issue 12, December 2025.The therapeutic potential of ataluren for NF1 nonsense mutations was assessed by a comprehensive evaluation of the RAS/MEK/ERK pathway activity in 22 NF1NS/+ patient‐derived fibroblasts. The whole‐transcriptomic profiles between ataluren responders and nonresponders, and further analysis and validation revealed novel biomarkers, AMPD3 and TGFBR3, for ...
Soyoung Kim +8 more
wiley +1 more source
Temporal Bayesian classifiers for modelling muscular dystrophy expression data [PDF]
, 2006 The analysis of microarray data from time-series experiments requires specialised algorithms, which take the temporal ordering of the data into account. In this paper we explore a new architecture of Bayesian classifier that can be used to understand how
Hoen, PAC't +3 more
core
MedComm, Volume 6, Issue 12, December 2025.Alternative splicing (AS) expands proteomic diversity and functional complexity in eukaryotes, regulated by spliceosomal components, RNA elements, and epigenetic modifications. Dysregulated AS contributes to diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, among others. Therapeutic interventions, such as antisense
Zhi‐Min Zhu +5 more
wiley +1 more source
534. Cell Therapeutic Approach to Duchenne Muscular Dystrophy Using Myogenic Differentiation of Multipotent Mesenchymal Stromal Cells [PDF]
, 2009 openalex +1 more source
Single‐Cell and Spatial Multiomics: Applications for Diseases
MedComm, Volume 6, Issue 12, December 2025.Schematic diagram of different single‐cell and spatial multiomics methods to describe the tissue layout of human diseases. ABSTRACT Complex and dynamic networks of molecules are involved in human diseases. Single‐cell and spatial multiomics approaches have created new avenues for understanding the pathogenesis and diagnosis of diseases.
Wentao Li +3 more
wiley +1 more source
Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model [PDF]
, 2023 Yosuke Hiramuki +14 more
openalex +1 more source
Feasibility of a Home‐Based Exergaming Intervention for Youth With Spinal Muscular Atrophy
Muscle &Nerve, Volume 72, Issue 6, Page 1259-1264, December 2025.ABSTRACT Introduction/Aims Approaches to optimize physical activity in youth with spinal muscular atrophy (SMA) are rapidly evolving. The primary objective of this study was to assess the feasibility of a fit‐for‐purpose home‐based exergaming intervention in children and youth with SMA and peer controls.
Ihsane Iraqi +17 more
wiley +1 more source
Noncompaction in Duchenne Muscular Dystrophy
Internal Medicine, 2016 Josef, Finsterer, Sinda, Zarrouk-Mahjoub
openaire +6 more sources