Results 61 to 70 of about 230,249 (259)

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance [PDF]

, 2017
Intratumoral phenotypic heterogeneity has been described in many tumor types, where it can contribute to drug resistance and disease recurrence. We analyzed ductal and neuroendocrine markers in pancreatic ductal adenocarcinoma, revealing heterogeneous ...
Jason Link, Andrew D. Rhim, Amy S. Farrell, Egbukichi, Nkolika, Owen J. Sansom, Rosalie C. Sears, Meghan Morrison Joly, Christian Lanciault, Mary C. Thoma, Muthalagu, Nathiya, Jenny, Zina P., Nathiya Muthalagu, Lanciault, Christian, Sauer, David, Nicholas D. Kendsersky, Sara L. Manning, Joly, Meghan Morrison, Thoma, Mary C., Sheppard, Brett C., Allen-Petersen, Brittany L., David Sauer, Jennifer P. Morton, Taylor S. Amery, Rhim, Andrew D., Laura M. Heiser, Murphy, Daniel J., Sansom, Owen J., Kendsersky, Nicholas D., Carl Pelz, Farrell, Amy S., Worth, Patrick J., Brett C. Sheppard, Heiser, Laura M., Daniel J. Murphy, Megan T. Hoffman, Amery, Taylor S., Crawford, Howard C., Nkolika Egbukichi, Hoffman, Megan T., Patrick J. Worth, Howard C. Crawford, Morton, Jennifer P., Pratt, Erica D., Sears, Rosalie C., Pelz, Carl, Manning, Sara L., Brittany L. Allen-Petersen, Zina P. Jenny, Erica D. Pratt, Link, Jason   +49 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Epithelial‐myoepithelial carcinoma occurrence in the site of previously treated ductal carcinoma in situ of the breast: Imaging features with histopathologic correlation, a case report and review of the literature

Clinical Case Reports
Key Clinical Message Epithelial‐myoepithelial carcinoma of the breast is an extremely rare biphasic tumor. This report documents the first case of epithelial‐myoepithelial carcinoma presenting in the location of a previously treated ductal carcinoma in ...
Jessica Hui, Xin Zhan, Amani Bashir, Fabiana Policeni, Su Kim Hsieh   +4 more
doaj   +1 more source

Pancreatic ductal bicarbonate secretion: challenge of the acinar acid load

Frontiers in Physiology, 2011
Acinar and ductal cells of the exocrine pancreas form a close functional unit. Although most studies contain data either on acinar or ductal cells, an increasing number of evidence highlights the importance of the pancreatic acinar-ductal functional unit.
Peter eHegyi, Jozsef eMaléth, Viktória eVenglovecz, Zoltan eRakonczay   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Clinicopathological significance of MYL9 expression in pancreatic ductal adenocarcinoma

Cancer Reports, 2022
Background Pancreatic ductal adenocarcinoma is one of the most aggressive malignancies, and often involves invasion and distant metastasis from the early tumor stages.
Katsunori Matsushita, Shogo Kobayashi, Hirofumi Akita, Masamitsu Konno, Ayumu Asai, Takehiro Noda, Yoshifumi Iwagami, Tadafumi Asaoka, Kunihito Gotoh, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii   +12 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The clinical behavior of mixed ductal/lobular carcinoma of the breast: a clinicopathologic analysis

World Journal of Surgical Oncology, 2010
Background To date, the clinical presentation and prognosis of mixed ductal/lobular mammary carcinomas has not been well studied, and little is known about the outcome of this entity. Thus, best management practices remain undetermined due to a dearth of
Dunnington Gary, Banisaeed Nassim, Paruchuri Lakshmi P, Suryadevara Aparna, Rao Krishna A   +4 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source