Results 171 to 180 of about 213,451 (221)
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Study on the binding of chiral drug duloxetine hydrochloride to human serum albumin

European Journal of Medicinal Chemistry, 2010
Duloxetine holds a special promise as an antidepressant, and its effect depends on its binding to human serum albumin (HSA). For this reason, the binding mechanism of duloxetine with HSA was investigated. The specific binding site in HSA was identified and binding constants were determined.
Yingxiang Du
exaly   +3 more sources

Fast surface water quality analysis based on an ultra-sensitive determination of the antidepressant drug duloxetine hydrochloride on a diamond electrode by voltammetry

International Journal of Environmental Analytical Chemistry, 2020
Duloxetine hydrochloride (DUL) is an antidepressant drug that is being increasingly consumed and so, it is classified as an emerging pollutant. As it is found at very low concentration in the environment, in this work, we investigated the electrochemical
G. R. P. Manrique   +3 more
semanticscholar   +1 more source

Formulation Development and Evaluation of Duloxetine Hydrochloride Multi-Particulate Delayed-Release Capsules

International Journal of Pharmaceutical Investigation, 2020
Background: Multi-particulate drug delivery systems are mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some desired characteristics.
Suseem Sr Suseem, Dhanish Joseph
semanticscholar   +1 more source

An Improved Process for Synthesis of (S)-Duloxetine Hydrochloride Involving Enzymatic Asymmetric Carbonyl Reduction on a Novel Ketoamine

, 2020
(S)-Duloxetine hydrochloride 1 is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia and neuropathic pain (Figure 1).
Sachin Arun Sasane   +5 more
semanticscholar   +1 more source

Formulation, Optimization of Duloxetine Hydrochloride Loaded Oral Fast Dissolving Films: In vitro and Ex vivo Evaluation

International Journal of Drug Delivery Technology
Introduction: Duloxetine hydrochloride (DLX) is a poorly water-soluble antidepressant with low oral bioavailability (~32%) due to acid-mediated degradation in the stomach and extensive first-pass metabolism.
M. M.   +6 more
semanticscholar   +1 more source

Duloxetine Hydrochloride (Cymbalta)

2015
“To live is to suffer, to survive is to find some meaning in the suffering.” Nietzsche’s words ring true to many. Depression is romanticized at times due to its association with poets and artists, but in reality depression, especially major depressive disorder (MDD), can be debilitating. There are two types of depression: MDD and bipolar, also known as
openaire   +1 more source

A Comparative Chemometric Study for Quantitative Determination of Duloxetine Hydrochloride in the Presence of its Toxic Impurity 1-Naphthol

, 2020
Duloxetine hydrochloride (DUL) is a serotonin-norepinephrine reuptake inhibitor. It is used for treating depression and anxiety. It is available in the market as a capsule called Cymbatex®, which is used for the treatment of depression. 1-naphthol is a
Basma H. Anwar   +3 more
semanticscholar   +1 more source

Case Report: Fulminant Hepatic Failure Involving Duloxetine Hydrochloride

Clinical Gastroenterology and Hepatology, 2006
Duloxetine hydrochloride was approved by the Food and Drug Administration in August 2004 for the treatment of major depressive disorder and diabetic peripheral neuropathic pain. Initial product labeling contained a precaution regarding the risk for increases in liver function test results.
A James, Hanje   +4 more
openaire   +2 more sources

Validation of a stability-indicating HPTLC method for analysis of duloxetine hydrochloride in capsule dosage form. Separation and analysis of duloxetine hydrochloride and olanzapine in a synthetic mixture

Journal of Planar Chromatography – Modern TLC, 2009
A simple, selective, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been established and validated for analysis of duloxetine hydrochloride in formulations. The compound was resolved on aluminum-backed silica gel 60 F254 plates with toluene-methanol-10% (v/v) ammonia 3:1.3:0.05 (v/v) as mobile phase ...
Sejal Patel   +5 more
openaire   +1 more source

Transmucosal Delivery of Duloxetine Hydrochloride for Prolonged Release: Preparation, in vitro, ex vivo Characteri-zation and in vitro-ex vivo Correlation

International Journal of Pharmaceutical Sciences and Nanotechnology, 2018
Duloxetine hydrochloride is a selective serotonin and nor adrenaline reuptake inhibitor. It is used in the treatment of depression, diabetic peripheral neuropathic pain and in moderate to severe stress urinary incontinence in women. However, it undergoes
Nagaraj Banala   +3 more
semanticscholar   +1 more source

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