Results 171 to 180 of about 3,570 (199)
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Study on the binding of chiral drug duloxetine hydrochloride to human serum albumin☆
European Journal of Medicinal Chemistry, 2010Duloxetine holds a special promise as an antidepressant, and its effect depends on its binding to human serum albumin (HSA). For this reason, the binding mechanism of duloxetine with HSA was investigated. The specific binding site in HSA was identified and binding constants were determined.
Yingxiang Du
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A validated UV spectrophotometric method for determination of duloxetine hydrochloride.
Die Pharmazie, 2007A simple, sensitive and accurate UV spectrophotometric method was developed for the assay of duloxetine hydrochloride in raw material and capsules. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 290 nm for duloxetine capsule solution.
Kamila, M. M., Mondal , N., Ghosh, L. K.
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Case Report: Fulminant Hepatic Failure Involving Duloxetine Hydrochloride
Clinical Gastroenterology and Hepatology, 2006Duloxetine hydrochloride was approved by the Food and Drug Administration in August 2004 for the treatment of major depressive disorder and diabetic peripheral neuropathic pain. Initial product labeling contained a precaution regarding the risk for increases in liver function test results.
A James, Hanje +4 more
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Optimization and in vivo evaluation of duloxetine hydrochloride buccoadhesive lyophilized tablets
Journal of Drug Delivery Science and Technology, 2019Abstract Duloxetine hydrochloride (DH) is a serotonin-norepinephrine reuptake inhibitor (SSNRI) indicated for the treatment of depression. Duloxetine suffers from reduced oral bioavailability (≈50%) due to hepatic metabolism. DH buccoadhesive lyophilized tablets were prepared adopting the solvent casting/freeze drying method using HPMC, chitosan and ...
Ahmed Hassen Elshafeey
exaly +2 more sources
Pharmaceutical Chemistry Journal, 2020
Duloxetine hydrochloride (DLX) is a serotonin and noradrenalin reuptake inhibitor mostly used for the treatment of major depressive and anxiety disorders. Physicochemical characterization of this drug and compatibility studies with excipients are particularly important during pharmaceutical technology development in order to guarantee the quality, safe
Andressa Veiga +8 more
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Duloxetine hydrochloride (DLX) is a serotonin and noradrenalin reuptake inhibitor mostly used for the treatment of major depressive and anxiety disorders. Physicochemical characterization of this drug and compatibility studies with excipients are particularly important during pharmaceutical technology development in order to guarantee the quality, safe
Andressa Veiga +8 more
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Journal of Planar Chromatography – Modern TLC, 2009
A simple, selective, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been established and validated for analysis of duloxetine hydrochloride in formulations. The compound was resolved on aluminum-backed silica gel 60 F254 plates with toluene-methanol-10% (v/v) ammonia 3:1.3:0.05 (v/v) as mobile phase ...
Sejal Patel +5 more
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A simple, selective, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been established and validated for analysis of duloxetine hydrochloride in formulations. The compound was resolved on aluminum-backed silica gel 60 F254 plates with toluene-methanol-10% (v/v) ammonia 3:1.3:0.05 (v/v) as mobile phase ...
Sejal Patel +5 more
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Duloxetine Hydrochloride (Cymbalta)
2015“To live is to suffer, to survive is to find some meaning in the suffering.” Nietzsche’s words ring true to many. Depression is romanticized at times due to its association with poets and artists, but in reality depression, especially major depressive disorder (MDD), can be debilitating. There are two types of depression: MDD and bipolar, also known as
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Clinical Therapeutics, 2005
Duloxetine hydrochloride has recently been approved by the US Food and Drug Administration for the treatment of major depressive disorder (MDD). Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake, with weak effects on dopamine reuptake.This article reviews the literature on duloxetine with regard to its pharmacodynamics ...
Lynn Crismon
exaly +3 more sources
Duloxetine hydrochloride has recently been approved by the US Food and Drug Administration for the treatment of major depressive disorder (MDD). Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake, with weak effects on dopamine reuptake.This article reviews the literature on duloxetine with regard to its pharmacodynamics ...
Lynn Crismon
exaly +3 more sources
Formulation and Evaluation of Microemulsion-based Transdermal Delivery of Duloxetine Hydrochloride
International Journal of Pharmaceutical Sciences and Nanotechnology, 2019Duloxetine Hydrochloride (DH), is a selective serotonin and nor-adrenaline reuptake inhibitor, used in the treatment of depression, diabetic peripheral neuropathic pain and moderate to severe stress urinary incontinence in women. It has high first-pass metabolism and undergoes degradation in acidic environment, leads to poor oral bioavailability. Here,
Sushma P. +3 more
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Treatment of stress urinary incontinence with duloxetine hydrochloride.
Reviews in urology, 2011Currently, there are no approved medications for the treatment of stress urinary incontinence (SUI) in the United States. The effectiveness of duloxetine in the treatment of SUI is linked to its inhibition of presynaptic neuronal reuptake of serotonin and norepinephrine in the central nervous system, resulting in elevated levels of serotonin and ...
Danielle D, Sweeney +1 more
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