Results 21 to 30 of about 366,938 (291)

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

open access: yesAdvanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen   +12 more
wiley   +1 more source

TFE3 regulates whole‐body energy metabolism in cooperation with TFEB

open access: yesEMBO Molecular Medicine, 2017
TFE3 and TFEB are members of the MiT family of HLH–leucine zipper transcription factors. Recent studies demonstrated that they bind overlapping sets of promoters and are post‐transcriptionally regulated through a similar mechanism.
Nunzia Pastore   +8 more
doaj   +1 more source

Collaboration with Nlaka'pamux communities to examine metal deposition on soapberry in interior British Columbia

open access: yesEcosphere, 2021
This paper presents a collaboration with Indigenous Nlaka'pamux communities to develop a study to address the effects of mining dust on soapberry (Shepherdia canadensis), which is an important medicinal and food resource for local Nlaka'pamux people. The
Kevan Berg   +5 more
doaj   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

open access: yesAdvanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song   +9 more
wiley   +1 more source

Ionic Liquid Electrolytes for Extreme Temperature Conditions: Challenges and Perspective

open access: yesAngewandte Chemie, EarlyView.
Ionic liquids (ILs) have gained great attention as safe electrolyte components in recent years. This review elucidates the temperature effects on IL‐based electrolytes from molecular configurations, physicochemical properties, and interfacial chemistry, raises the challenges and design strategies operating at low‐ and HT, providing valuable guidance ...
En Xie   +11 more
wiley   +2 more sources

Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice

open access: yesFrontiers in Neural Circuits, 2013
The cerebellum is organized into zonal circuits that are thought to regulate ongoing motor behavior. Recent studies suggest that neuronal birthdates, gene expression patterning, and apoptosis control zone formation.
Stacey L Reeber   +3 more
doaj   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

open access: yesAdvanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia   +10 more
wiley   +1 more source

A Large Scale Multi‐Modal Workflow for Battery Characterization: From Concept to Implementation

open access: yesAdvanced Energy Materials, EarlyView.
Isolated characterization techniques produce independent datasets and single‐property insights. However, progressively more holistic interpretations of battery‐material behavior is needed in the future. Here we demonstrate a coordinated multimodal workflow enabling the correlation of heterogeneous datasets and the construction of multidimensional ...
François Cadiou   +34 more
wiley   +1 more source

PrecivityAD2™ Blood Test: Analytical Validation of an LC-MS/MS Assay for Quantifying Plasma Phospho-tau217 and Non-Phospho-tau217 Peptide Concentrations That Are Used with Plasma Amyloid-β42/40 in a Multianalyte Assay with Algorithmic Analysis for Detecting Brain Amyloid Pathology

open access: yesDiagnostics
Alzheimer’s disease (AD) is a progressive irreversible neurodegenerative disorder that represents a major global public health concern. Traditionally, AD is diagnosed using cerebrospinal fluid biomarker analysis or brain imaging modalities.
Stephanie M. Eastwood   +10 more
doaj   +1 more source

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression

open access: yesJournal of Neuroinflammation, 2020
Background Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, neuroinflammation, and neurodegeneration.
Gayathri Sundaram   +3 more
doaj   +1 more source

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