Results 31 to 40 of about 118,707 (267)

Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice

Frontiers in Neural Circuits, 2013
The cerebellum is organized into zonal circuits that are thought to regulate ongoing motor behavior. Recent studies suggest that neuronal birthdates, gene expression patterning, and apoptosis control zone formation.
Stacey L Reeber, Courtney A. Loeschel, Amanda eFranklin, Roy V Sillitoe   +3 more
doaj   +1 more source

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression

Journal of Neuroinflammation, 2020
Background Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, neuroinflammation, and neurodegeneration.
Gayathri Sundaram, Chai K. Lim, Bruce J. Brew, Gilles J. Guillemin   +3 more
doaj   +1 more source

Elevated NRAS expression during DCIS is a potential driver for progression to basal-like properties and local invasiveness

Breast Cancer Research, 2022
Background Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant breast cancers. What drives DCIS to invasive breast cancer is unclear. Basal-like invasive breast cancers are aggressive.
Ze-Yi Zheng, Hanan Elsarraj, Jonathan T. Lei, Yan Hong, Meenakshi Anurag, Long Feng, Hilda Kennedy, Yichao Shen, Flora Lo, Zifan Zhao, Bing Zhang, Xiang H.-F. Zhang, Ossama W. Tawfik, Fariba Behbod, Eric C. Chang   +14 more
doaj   +1 more source

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

Advanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu, Shiming Zhu, Sishi Xia, Xiaoshuai Zhang, Qin Li, Zhanquan Zeng, Yuqing Liu, Wanyin Liang, Guanyu Zhou, Erxia Du, Suning Liu, Sheng Li   +11 more
wiley   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

Understanding the current state-of-the-art of long-lasting insecticide nets and potential for sustainable alternatives

Current Research in Parasitology and Vector-Borne Diseases, 2022
Long-lasting insecticide-treated nets (LLINs) are widely distributed to communities where malaria is a major cause of mortality, especially to those under the age of 5 years-old.
Sydney Brake, Diego Gomez-Maldonado, Michael Hummel, Sarah Zohdy, Maria S. Peresin   +4 more
doaj   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source

PrecivityAD2™ Blood Test: Analytical Validation of an LC-MS/MS Assay for Quantifying Plasma Phospho-tau217 and Non-Phospho-tau217 Peptide Concentrations That Are Used with Plasma Amyloid-β42/40 in a Multianalyte Assay with Algorithmic Analysis for Detecting Brain Amyloid Pathology

Diagnostics
Alzheimer’s disease (AD) is a progressive irreversible neurodegenerative disorder that represents a major global public health concern. Traditionally, AD is diagnosed using cerebrospinal fluid biomarker analysis or brain imaging modalities.
Stephanie M. Eastwood, Matthew R. Meyer, Kristopher M. Kirmess, Traci L. Wente-Roth, Faith Irvin, Mary S. Holubasch, Philip B. Verghese, Tim West, Joel B. Braunstein, Kevin E. Yarasheski, John H. Contois   +10 more
doaj   +1 more source

Does the Duncan-Ely test predict abnormal activity of the rectus femoris in stroke survivors with a stiff knee gait?

Journal of Rehabilitation Medicine, 2022
Objective: To determine the diagnostic value of the Duncan-Ely test in predicting abnormal rectus femoris activity during gait in stroke survivors walking with a stiff knee gait. Design: Cross-sectional diagnostic study.
Martin J. B. Tenniglo, Marc J. Nederhand, Judith F. Fleuren, Johan S. Rietman, Jaap H. Buurke, Erik C. Prinsen   +5 more
doaj   +1 more source

High Power Density, Low Temperature, Solid Oxide Fuel Cells at Elevated Oxygen Partial Pressure

Advanced Energy Materials, EarlyView.
Elevated pO2${{p}_{{{{\mathrm{O}}}_2}}}$ improves oxygen reduction reaction (ORR) kinetics, thus reducing electrode area specific resistance (ASR). The effect of pO2${{p}_{{{{\mathrm{O}}}_2}}}$ in open circuit potential (OCP) and ASR is demonstrated on both Sr0.5Sm0.5CoO3‐δ‐Gd0.1Ce0.9O2‐δ (SSC‐GDC) composite cathodes and our recently developed nano‐PSC
Samuel A. Horlick, Yi‐Lin Huang, Keith L. Duncan, Aniqa Anjum, Nathan B. Johnson, Alexandra P. Lam, Ian A. Robinson, Eric D. Wachsman   +7 more
wiley   +1 more source