Results 51 to 60 of about 20,527 (318)

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Feasibility of continued treatment with dupilumab in patients with type 2 inflammatory disease who developed eosinophilic pneumonia: 3 case reports

Respirology Case Reports
Several reports have described dupilumab‐induced eosinophilic pneumonia (EP) after treatment with dupilumab in patients with type 2 inflammatory disease. Other reports have suggested the efficacy of dupilumab for chronic EP (CEP).
Masamitsu Hamakawa, Ayaka Tanaka, Fumiaki Tokioka, Tadashi Ishida   +3 more
doaj   +1 more source

Incidence of Conjunctivitis and Keratitis Among Individuals with Moderate-to-Severe Atopic Dermatitis Treated with Dupilumab in the United States: a Cohort Study in Routine Care Based on Healthcare Claims

Dermatology and Therapy
Introduction In clinical trials of patients with atopic dermatitis (AD), conjunctivitis and keratitis occurred more frequently with dupilumab than placebo.
Jessica M. Franklin, Andrea F. Marcus, Ihtisham Sultan, Ashley Howell, Sarah-Jo Sinnott, Jeannette Green, Stephen Ezzy, Robert Gately, Rachel E. Sobel, Florence T. Wang   +9 more
doaj   +1 more source

We Have to Learn to Do Without Knowing Enough: Anti-Eosinophilic Treatments for Severe Asthma [PDF]

, 2018
Interleukin.5 (IL.5) is the main eosinophilic cytokine that promotes the differentiation, survival, and activation of eosinophils, which are the key inflammatory cells in severe eosinophilic asthma .Thus, it is no surprise that ...
4,, BEGHE', Bianca, Fabbri, Lm3, Papi, A1   +3 more
core   +1 more source

Pengaruh terapi dupilumab pada dermatitis atopik sedang hingga berat [PDF]

, 2021
AbstrakDupilumab merupakan antibodi monoklonal yang bekerja spesifik sebagai antagonis reseptor-α IL-4 yang menghambat kedua pensinyalan IL-4 dan IL-13 pada reseptor IL-4.
Ardiana, Dian, Chandra, Eka Narayana, Purnomo, Elaine   +2 more
core   +1 more source

Cost‐utility analysis of sequential therapies for pediatric‐onset eosinophilic esophagitis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Topical corticosteroids, proton‐pump inhibitors (PPI) and elimination diets (ED) are equally recommended as first‐line therapies for pediatric eosinophilic esophagitis (EoE). Dupilumab (DUP) is usually used for refractoriness. We aim to assess the cost‐utility of all potential sequential treatments for EoE.
José Vicente Arcos‐Machancoses, Elena Crehuá‐Gaudiza, Cecilia Martínez‐Costa   +2 more
wiley   +1 more source

Facial erythema after the treatment of dupilumab in SLE patient

Allergy, Asthma & Clinical Immunology, 2020
Background Dupilumab is a receptor antagonist binding to the alpha subunit of the interleukin-4 receptor. Through binding to it, dupilumab inhibits signaling of both IL-4 and IL-13, the representative Th2 biomarkers.
Dong Hyek Jang, Jae In Lee, Joo Yoon Bae, Hye Jung Jung, Mi Yeon Park, Jiyoung Ahn   +5 more
doaj   +1 more source

Keratoconjunctivitis associated with atopic dermatitis treated with tocilizumab [PDF]

, 2018
La dermatitis atópica es una enfermedad cutánea inflamatoria crónica, de diagnóstico esencialmente clínico que se manifiesta en forma de prurito y brotes recurrentes de eccema de localización típica 1 .
Ferrando Piqueres, Raúl, Pitarch Bort, Gerard, Raga Jiménez, Celia, Álvarez Martín, Tamara   +3 more
core   +4 more sources

Barriers to treatment adherence in pediatric eosinophilic esophagitis

JPGN Reports, EarlyView.
ABSTRACT Objectives Treatment adherence in pediatric patients with eosinophilic esophagitis (EoE) is suboptimal. This study aimed to identify barriers to adherence, comparing experiences between patients on elimination diets and those prescribed medication.
Julia Primo, George Tankosich, Kristen Critelli, Elizabeth Sinclair   +3 more
wiley   +1 more source

Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis

American Journal of Ophthalmology Case Reports, 2020
Purpose: To describe a case of corneal ulceration associated with dupilumab use for atopic dermatitis. Observations: A patient developed an inflammatory corneal ulcer 3 weeks after starting bi-weekly intravenous dupilumab therapy.
Gavin Li, Meghan Berkenstock, Uri Soiberman   +2 more
doaj