Results 61 to 70 of about 24,787 (310)

Molecularly targeted therapies for asthma: current development, challenges and potential clinical translation [PDF]

, 2016
Extensive research into the therapeutics of asthma has yielded numerous effective interventions over the past few decades. However, adverse effects and ineffectiveness of most of these medications especially in the management of steroid resistant severe ...
Lim, Jonathan Chee Woei, Soo, Hon Liong, Stanslas, Johnson, Sulaiman, Ibrahim   +3 more
core   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Effectiveness of transitioning from omalizumab to dupilumab in chronic spontaneous urticaria patients with inadequate response to omalizumab

World Allergy Organization Journal
Dupilumab is effective for chronic spontaneous urticaria (CSU), but its clinical benefit of switching to dupilumab in omalizumab-resistant CSU remains unclear.This prospective pilot study evaluated the effectiveness of dupilumab in 12 CSU patients whose ...
Koremasa Hayama, M.D., Ph.D., Mana Ito-Watanabe, M.D., Ph.D., Hideki Fujita, M.D., Ph.D.   +2 more
doaj   +1 more source

Effect of dupilumab on otitis media associated with eosinophilic chronic rhinosinusitis

Brazilian Journal of Otorhinolaryngology
Objective: Eosinophilic Otitis Media (EOM) is an intractable disease caused by type 2 inflammation, such as Eosinophilic Chronic Rhinosinusitis (ECRS) and bronchial asthma. Biologics have recently been used to treat ECRS and bronchial asthma.
Seiichiro Kamimura, Keisuke Ishitani, Ryota Morozumi, Eiji Kondo, Takahiro Azuma, Go Sato, Yoshiaki Kitamura   +6 more
doaj   +1 more source

Rhinology future debates, an EUFOREA report [PDF]

, 2017
The first Rhinology Future Debates was held in Brussels in December 2016, organized by EUFOREA (European Forum for Research and Education in Allergy and Airways diseases).
Bachert, Claus, Bernal-Sprekelsen, Manuel, Bousquet, Jean, Djandji, Michel, Dorenbaum, Alejandro, Fokkens, Wytske J, Hakim-Mehr, Dorna, Hellings, Peter W, Hendry, Stuart, Hopkins, Claire, Leunig, Andreas, Mannent, Leda, Mucha, Dirk, Onerci, Metin, Pugin, Benoit, Rowe, Paul, Seys, Sven F, Stimson, Susan, Strzembosz, Agnieszka, Toppila-Salmi, Sanna   +19 more
core   +2 more sources

44290 Case of vitiligo after initiation of dupilumab therapy [PDF]

, 2023
Elnara Muradova, Evan Baird, Kristin Torre, Donna Aiudi, Katalin Ferenczi   +4 more
openalex   +1 more source

Successful treatment of eosinophilic esophagitis with upadacitinib prescribed for atopic dermatitis

JPGN Reports, EarlyView.
Abstract We describe a pediatric patient treated with upadacitinib for atopic dermatitis (AD) who subsequently achieved sustained clinical and histologic remission of eosinophilic esophagitis (EoE). Upadacitinib is an oral small molecule selective Janus kinase 1 inhibitor that inhibits janus kinase‐signal transduction and activation of transcription ...
Nathalie Nguyen, Maureen Bauer
wiley   +1 more source

Co-Treatment with Steroid and Dupilumab for Eosinophilic Chronic Rhinosinusitis after Eosinophilic Pneumonitis Caused by Dupilumab

Ear, Nose & Throat Journal
Eosinophilic chronic rhinosinusitis (ECRS) is a Type 2 inflammatory disease that manifests as chronic inflammation of the paranasal sinus. IL-4/IL-13 receptor monoclonal antibodies (dupilumab) to suppress Type 2 inflammation have become a good treatment ...
Takato Sudo MD, Takeshi Tsuda MD, PhD, Masaki Hayama MD, PhD, Kazuya Takeda MD, PhD, Sho Obata MD, Ayaka Nakatani MD, Yuta Amano MD, Soichiro Fujii MD, Hiroko Fukata MD, Hidenori Inohara MD, PhD   +9 more
doaj   +1 more source

The use of dupilumab in severe atopic dermatitis during pregnancy: a case report

Allergy, Asthma & Clinical Immunology, 2022
Background Atopic dermatitis is a common chronic skin disease that can occur in pregnancy. Current treatments include topical and systemic glucocorticoids and cyclosporine.
Nabeel H. Akhtar, Touraj Khosravi-Hafshejani, Daud Akhtar, Gurbir Dhadwal, Amin Kanani   +4 more
doaj   +1 more source

Long-term dupilumab treatment for chronic refractory generalized prurigo nodularis: A retrospective cohort study [PDF]

, 2021
Jorge R. Georgakopoulos, David Croitoru, Tina Felfeli, Raed Alhusayen, Perla Lansang, Neil H. Shear, Jensen Yeung, Scott R. Walsh   +7 more
openalex   +1 more source