Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
flowSim: Near duplicate detection for flow cytometry data. [PDF]
Cytometry A, 2023 Montante S, Chen Y, Brinkman RR.
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Multifile Partitioning for Record Linkage and Duplicate Detection. [PDF]
J Am Stat Assoc, 2023 Aleshin-Guendel S, Sadinle M.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discovering Near Duplicate Text in Software Documentation
Труды Института системного программирования РАН, 2018 Development of software documentation often involves copy-pasting, which produces a lot of duplicate text. Such duplicates make it difficult and expensive documentation maintenance, especially in case of long life cycle of software and its documentation.
L. D. Kanteev +4 more
doaj +1 more source
Duplicate Detection of Spike Events: A Relevant Problem in Human Single-Unit Recordings. [PDF]
Brain Sci, 2021 Dehnen G +7 more
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Detecting Duplicate Effort in GitHub Contributions [PDF]
Proceedings of the 20th International Conference on Evaluation of Novel Approaches to Software EngineeringThe pull-based development model allows collaborators to develop and propose changes to a codebase. However, pull requests can often offer duplicate functionality and therefore duplicate effort. Users can also request changes via issues, the text of which could provide clues, useful in determining duplicate pull requests.
James Galbraith, Des Greer
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source