Results 211 to 220 of about 209,245 (257)

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Evolutionary Changes of <i>GT1</i> Provide Insights Into the Adaptation of Butterflies to Plant Feeding. [PDF]

Ecol Evol
Wu J, Yan H, Tang W, Li Z, Chakraborty A, He Z, Zhou C, He S.   +7 more
europepmc   +1 more source

Parasitic Plant–Host Interactions: Molecular Mechanisms and Agricultural Resistance Strategies

Advanced Science, EarlyView.
Parasitic plants devastate global agriculture through sophisticated molecular interactions with host crops. This review synthesizes current understanding of parasitic plant‐host interactions, from strigolactone‐mediated germination and haustorium formation to host defense mechanisms.
Jiayang Shi, Qi Xie, Feifei Yu
wiley   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Mitochondrial Genome Characterization of Six Spiny Crawler Mayflies and Comparative Analysis Within Ephemerellidae (Ephemeroptera: Pannota). [PDF]

Ecol Evol
Xue C, Ma Z, Liu D, Li R, Yi X.
europepmc   +1 more source

Cross‐Platform Biosensing of Immune Receptors Using Peptide‐Functionalized Graphene

Advanced Science, EarlyView.
A peptide‐functionalized graphene biosensor enables sensitive and selective detection of living immune cells. Targeting Formyl‐Peptide Receptor 2 (FPR2), the assay is demonstrated on model cells and primary human neutrophils. The same assay is applied to two complementary platforms: graphene‐enhanced surface plasmon resonance for optical benchmarking ...
Ahmar Hasnain, Heiko Heilmann, Annabel Pohl, Celine Weber, Bernd Bufe, Alexey Tarasov   +5 more
wiley   +1 more source

Complete Mitochondrial Genomes of <i>Pentapodus caninus</i> and <i>Lethrinus olivaceus</i> (Spariformes: Nemipteridae and Lethrinidae): Genome Characterization and Phylogenetic Analysis. [PDF]

Animals (Basel)
Chen N, Gu M, Jiang W, Xie L, Qiao Q, Cen J, Dong Y, Lu S, Cui L.   +8 more
europepmc   +1 more source

Re-biopsy and modified biopsy in mosaic human embryos with simple segmental chromosomal deletion. [PDF]

Reprod Biol Endocrinol
Wang W, Liu B, Jin Z, Chen F, Wang X, Yin X, Shang W, Chuai Y.   +7 more
europepmc   +1 more source

Genetic and <i>in silico</i> functional characterization of a novel structural variant in the <i>PAH</i> gene by long-reads sequencing and structural modeling. [PDF]

Front Genet
Gallardo V, Gaete A, Maldonado J, Morales P, Peña A, Hamilton V, Faundes V, Santa María L.   +7 more
europepmc   +1 more source

Designing Peptide Fossils That Model the Evolution of the Bacterial Ferredoxin Fold. [PDF]

JACS Au
Jagilinki BP, Campbell I, Tyryshkin AM, Mutter AC, Siess J, DiGiacomo J, Klein D, Poudel S, Falkowski PG, Silberg JJ, Nanda V.   +10 more
europepmc   +1 more source