Results 121 to 130 of about 315,042 (319)
Insights into System-Wide Code Duplication
, 2004 Duplication of code is a common phenomenon in the development and maintenance of large software systems. The detection and removal of duplicated code has become a standard activity during the refactoring phases of a software life-cycle.
Matthias Rieger +5 more
core +1 more source
Duplication appendiculaire révélé à l'occasion d'un syndrome appendiculaire récidivant
The Pan African Medical Journal, 2015 La duplication appendiculaire est une malformation très rare. Elle se rencontre chez les enfants exceptionnellement chez les adultes. Sa découverte est souvent fortuite à l'occasion d'une laparotomie ou laparoscopie pour une autre pathologie.
Younes Aggouri +6 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication.
, 2016 Approximately 30% of tumor endothelial cells have over-duplicated (>2) centrosomes, which may contribute to abnormal vessel function and drug resistance.
Zhixian Yu (3560171) +11 more
core +1 more source
Frontiers in SurgeryBackgroundThe anterior communicating artery (AComA) is a common site for intracranial aneurysms due to its complex vascular architecture. Fenestrations in the AComA, observed in 7.5%–40% of cases, can disrupt normal blood flow, which increases turbulence
Ufuk Erginoglu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.RETRACTION: S. Gopinath, K. Alapati, R. R. Malla, C. S. Gondi, S. Mohanam, D. H. Dinh, and J. S. Rao, “Mechanism of p27 Upregulation Induced by Downregulation of Cathepsin B and Upar in Glioma,” Molecular Oncology 5, no. 5 (2011): 426–437, https://doi.org/10.1016/j.molonc.2011.07.004.
wiley +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
, 2017 Renata Nacinovich,1,2 Nicoletta Villa,3 Fiorenza Broggi,1,2 Cristina Tavaniello,1 Monica Bomba,1 Donatella Conconi,2 Serena Redaelli,2 Elena Sala,3 Marialuisa Lavitrano,2 Francesca Neri1,2 1Childhood and Adolescence Neuropsychiatric Unit, San Gerardo ...
Redaelli S +9 more
core