Results 231 to 240 of about 315,042 (319)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Poliovirus 3Dpol polymerase region is essential for cleavage of poliovirus 3AB in vivo. [PDF]

PLoS Pathog
Arita M.
europepmc   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Two Patients with X Chromosome Duplication: dupXp and dupXq

Balkan Journal of Medical Genetics, 2009
Ozer O, Yilmaz Z, Simsek E, Derbent M, Guner S, Sahin F   +5 more
doaj   +1 more source

Long-read genome sequencing resolves a complex structural variant involving TBCD and exposes a gap in existing variant classification frameworks

Leslie J, Pagnamenta A, Harrold L, Ubeyratna N, Mallin L, Wenger O, Scott E, Puffenberger E, Cassidy E, Owens M, Baple E.   +10 more
europepmc   +1 more source

Urethral diverticulum following partial resection of a supernumerary urethra in Effman type IIA2 duplication: A case report. [PDF]

Urol Case Rep
Diallo TMO, Gnammi LR, Gamamou AV, Cherif A, Diallo TO, Diallo AB, Bah OR.   +6 more
europepmc   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

Genome-wide identification and expression pattern analysis of the COBRA-like gene family of Triticum aestivum (L.) under drought and heat stresses. [PDF]

BMC Plant Biol
Du C, Cui D, Zhou Z, Yang N, Chang Y, Zhu J.   +5 more
europepmc   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Characterization and evolution of the <i>GH3</i> gene family in <i>Nymphaea colorata</i>. [PDF]

Front Plant Sci
Li Z, Zhang Z, Li S, Xie J, Rong Y, Mu H.   +5 more
europepmc   +1 more source