Results 251 to 260 of about 315,042 (319)

Impacts of gene duplication in the evolution of symbiotic root nodule symbiosis in legumes. [PDF]

Front Plant Sci
Lee HO, Farmer AD, O'Rourke JA, Doyle JJ, Cannon SB.   +4 more
europepmc   +1 more source

Duplication in triplicate

Journal of British Surgery, 1963
openaire   +2 more sources

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

EXPRESSION OF CONCERN: Overexpression of TNKS1BP1 in Lung Cancers and Its Involvement in Homologous Recombination Pathway of DNA Double-Strand Breaks. [PDF]

Cancer Med
europepmc   +1 more source

Phylogenomics of Asgard archaea reveals a unique blend of prokaryotic-like horizontal transfer and eukaryotic-like gene duplication. [PDF]

Nat Commun
Manzano-Morales S, Gabaldón T.
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

The precision strategy of human genome correction via a set of circular donor DNA and its cleaver. [PDF]

Front Genome Ed
Kusano K, Takizawa K, Kawaguchi J, Hara I, Mori T.   +4 more
europepmc   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Dual Challenges: Addressing Post-Traumatic Retroperitoneal Urinoma in the Context of Pyeloureteral Duplication. [PDF]

Diagnostics (Basel)
Stan MD, Vlase I, Gheorghe E, Georgescu BA, Fasie D, Botnarciuc M, Herlo LF, Iorga IC, Voinea F, Nelson Twakor A, Cimpineanu B, Bratu IC.   +11 more
europepmc   +1 more source