Results 51 to 60 of about 315,042 (319)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Duplications of the alimentary tract in infants and children

Formosan Journal of Surgery, 2021
Background: Duplications of the alimentary tract are known for their embryonic, anatomical, clinical, and pathologic variations. Summarizing the features of these lesions would reveal these characteristics and guide appropriate management. The objectives
Rupesh Keshri, Ramjee Prasad, Digamber Chaubey, Zaheer Hasan, Vijayendra Kumar, Vinit Kumar Thakur, Ramdhani Yadav, Rakesh Kumar, Asjad Karim Bakhtiyar, Sandip Kumar Rahul   +9 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

06301 Summary – Duplication, Redundancy, and Similarity in Software [PDF]

, 2007
This paper summarizes the proceedings and outcomes of the Dagstuhl Seminar 06301. The purpose of the seminar was to bring together a broad selection of experts on duplication, redundancy, and similarity in software in order to: synthesize a ...
Walenstein, Andrew, Koschke, Rainer, Merlo, Ettore   +2 more
core   +1 more source

Gene duplication to the Y chromosome in Trinidadian Guppies [PDF]

, 2022
Differences in allele frequencies at autosomal genes between males and females in a population can result from two scenarios. First, unresolved sexual conflict over survival can produce allelic differentiation between the sexes.
Mank, JE, Darolti, I, Wright, AE, Mank, J.E., Benjamin A. Sandkam, Sandkam, B.A., Sandkam, BA, Wright, A.E., Yuying Lin, Almeida, P, Furman, B.L.S., Almeida, P., Judith E. Mank, Lin, Y., Alison E. Wright, Felix Breden, Iulia Darolti, Benjamin L. S. Furman, Pedro Almeida, Breden, F, Darolti, I., Breden, F., Lin, Y, Furman, BLS   +23 more
core   +1 more source

Predicting the Evolution of Syntenies—An Algorithmic Review

Algorithms, 2021
Syntenies are genomic segments of consecutive genes identified by a certain conservation in gene content and order. The notion of conservation may vary from one definition to another, the more constrained requiring identical gene contents and gene orders,
Nadia El-Mabrouk
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

06301 Abstracts Collection – Duplication, Redundancy, and Similarity in Software [PDF]

, 2007
From 23.07.06 to 26.07.06, the Dagstuhl Seminar 06301 ``Duplication, Redundancy, and Similarity in Software'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl. During the seminar, several participants presented their
Walenstein, Andrew, Koschke, Rainer, Merlo, Ettore   +2 more
core   +1 more source

A Meta-Analysis of α-Synuclein Multiplication in Familial Parkinsonism

Frontiers in Neurology, 2018
Chronic alpha-synuclein (SNCA) overexpression is a relatively homogenous and well-defined cause of parkinsonism and dementia. Parkinson's disease (PD), PD with dementia, dementia with Lewy bodies and multiple system atrophy all manifest in SNCA ...
Adam Book, Ilaria Guella, Tara Candido, Alexis Brice, Nobutaka Hattori, Beomseok Jeon, Matthew J. Farrer, SNCA Multiplication Investigators of the GEoPD Consortium   +7 more
doaj   +1 more source

Enteric Duplication [PDF]

Clinics in Colon and Rectal Surgery, 2018
AbstractEnteric duplications have been described throughout the entire gastrointestinal tract. The usual perinatal presentation is an abdominal mass. Duplications associated with the foregut have associated respiratory symptoms, whereas duplications in the midgut and hindgut can present with obstructive symptoms, perforation, nausea, emesis, hemorrhage,
Paul M, Jeziorczak, Brad W, Warner
openaire   +2 more sources