Results 71 to 80 of about 713,120 (303)
Cliques and duplication-divergence network growth
, 2005 A population of complete subgraphs or cliques in a network evolving via duplication-divergence is considered. We find that a number of cliques of each size scales linearly with the size of the network. We also derive a clique population distribution that
A Yuryev +13 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Properties of chains of prime ideals in an amalgamated algebra along an ideal
, 2010 Let $f:A \to B$ be a ring homomorphism and let $J$ be an ideal of $B$. In this paper, we study the amalgamation of $A$ with $B$ along $J$ with respect to $f$ (denoted by ${A\Join^fJ}$), a construction that provides a general frame for studying the ...
D'Anna, Marco +2 more
core +1 more source
Characterizations and Infinite Divisibility of Certain Recently Introduced Distributions IV [PDF]
, 2018 Certain characterizations of recently proposed univariate continuous distributions are presented in different directions. This work contains a good number of reintroduced distributions and may serve as a source of preventing the reinvention and/or ...
Hamedani, Gholamhossein G.
core +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Duplications of the critical Rubinstein-Taybi deletion region on chromosome 16p13.3 cause a novel recognisable syndrome [PDF]
, 2010 Background The introduction of molecular karyotyping technologies facilitated the identification of specific genetic disorders associated with imbalances of certain genomic regions.
Bena, F +23 more
core +2 more sources
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Human Genomics, 2010 Copy number variants (CNVs) create a major source of variation among individuals and populations. Array-based comparative genomic hybridisation (aCGH) is a powerful method used to detect and compare the copy numbers of DNA sequences at high resolution ...
Karimpour-Fard Anis +4 more
doaj +1 more source
Homological dimensions of the amalgamated duplication of a ring along a pure ideal [PDF]
, 2009 The aim of this paper is to study the classical global and weak dimensions of the amalgamated duplication of a ring $R$ along a pure ideal $I$
Chhiti, Mohamed, Mahdou, Najib
core