Results 31 to 40 of about 417,340 (287)
, 2022 S.147-208Finally, we will look into durability growth strategies and accelerated testing: In this chapter, materials and structures get an application background and, thus, testing is continued with structural coupons and full-scale components. Time- and
Heim, Rüdiger
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Development and Validation of a Thermomechanically Coupled Plasticity Model at Elevated Temperatures
Advances in Materials Science and EngineeringTraditional material models often fail to accurately capture the cyclic behaviour of metals under combined thermomechanical loads, which leads to significant discrepancies in predicting material performance at elevated temperatures.
Safa Yusuf Cetin +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 1958 The durability of buildings is a subject of timely importance in view of current changes in building types. The meaning of the term is explored. This leads to the suggestion that it is the question, “How much durability do you want in a building?” that must be faced by the designer.
Legget, R. F., Hutcheon, N. B.
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Fracture and Structural IntegrityMounting stiffness has an important impact on a system’s structural dynamics and also on the durability of many structures. Mounts with tunable stiffness allow adapting a system’s structural dynamic behavior.
Volker Landersheim +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Collusion and Durability [PDF]
We develop a model to show that cartels that produce goods with lower durability are easier to sustain implicitly. This observation gen- erates the following results: 1) implicit cartels have an incentive to pro- duce goods with an inefficiently low ...
Strausz, Roland, Sasaki, Dan
core +2 more sources