Results 41 to 50 of about 417,340 (287)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Design of Durable Goods

Marketing Science, 2011
The use of a durable good is limited by both its physical life and usable life. For example, an electric-car battery can last for five years (physical life) or 100,000 miles (usable life), whichever comes first. We propose a framework for examining how a profit-maximizing firm might choose the usable life, physical life, and selling price of a durable
Oded Koenigsberg, Rajeev Kohli, Ricardo Montoya   +2 more
openaire   +4 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Effect of Fly Ash as Cement Replacement on Chloride Diffusion, Chloride Binding Capacity, and Micro-Properties of Concrete in a Water Soaking Environment

Applied Sciences, 2020
This paper experimentally studies the effects of fly ash on the diffusion, bonding, and micro-properties of chloride penetration in concrete in a water soaking environment based on the natural diffusion law.
Jun Liu, Jiaying Liu, Zhenyu Huang, Jihua Zhu, Wei Liu, Wei Zhang   +5 more
doaj   +1 more source

Durability of Heat Treated Massive Poplar Plywood [PDF]

, 2022
Plywood made of poplar are limited to indoor usages since poplar exhibits a rather low natural durability. Recently, wood heat treatments are applied to improve properties such as decay susceptibility and dimensional stability.
THÉVENON, Marie-France, MARCON, Bertand, DENAUD, Louis, PIGNOLET, Luc, GARTILI, Adélaïde, VIGUIER, Joffrey, CANDELIER, Kevin, COLLET, Robert   +7 more
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Research on the mechanical properties and micro damage mechanism of water bearing sandstone under uniaxial compression

Scientific Reports
To provide a theoretical basis for the development of water hazard prevention schemes for roof sandstone, this study systematically conducts uniaxial compression, acoustic emission, scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS ...
Kaide Liu, Songxin Zhao, Lu Diao, Wenping Yue, Chaowei Sun, Yu Xia   +5 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Identification of water sources of mine water bursts based on the FPS-DT model

Scientific Reports
To effectively identify the source of water in coal mines and prevent water-related accidents, this paper utilises the hydrochemical characteristics of the aquifers Shanxi Hanzui Coal Mine.
Kaide Liu, Yu xia, Xiaolong Li, Chaowei Sun, Wenping Yue, Qiyu Wang, Songxin Zhao, Shufeng Chen   +7 more
doaj   +1 more source