Results 61 to 70 of about 1,189,034 (379)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Tree crown architecture: a tool for decay resistance evaluation [PDF]

open access: yes, 2013
The variability of natural durability contributes to the bad perception of some wood end-users. In our search, we need to adjust our methods and strategies to estimate natural durability and extract higher value from wood resources.
Amissa Adima, Augustin   +5 more
core  

Research on the mechanical properties and micro damage mechanism of water bearing sandstone under uniaxial compression

open access: yesScientific Reports
To provide a theoretical basis for the development of water hazard prevention schemes for roof sandstone, this study systematically conducts uniaxial compression, acoustic emission, scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS ...
Kaide Liu   +5 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Durability of protection post-primary COVID-19 vaccination in the US: matched case-control study [PDF]

open access: green, 2022
Amanda B. Zheutlin   +10 more
openalex   +1 more source

Studies on durability of sustainable biobased composites: a review

open access: yesRSC Advances, 2020
Global concerns over environmental issues have led to a tremendous growth in sustainable materials emerging from biobased plastics and their composites (biocomposites).
B. P. Chang, A. Mohanty, M. Misra
semanticscholar   +1 more source

Identification of water sources of mine water bursts based on the FPS-DT model

open access: yesScientific Reports
To effectively identify the source of water in coal mines and prevent water-related accidents, this paper utilises the hydrochemical characteristics of the aquifers Shanxi Hanzui Coal Mine.
Kaide Liu   +7 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

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