Results 41 to 50 of about 32,258 (304)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Estimating normal duration of renovation for multistory apartment building considering extension-type renovation projects

Journal of Civil Engineering and Management, 2019
Normal (typical) project duration is estimated at the initial stage of a renovation project and is an important reference for project control. However, its estimation has not been researched extensively owing to the complexity and uncertainties of ...
Jongsik Yoon, Ilhan Yu
doaj   +1 more source

A pan-African medium-range ensemble flood forecast system [PDF]

Hydrology and Earth System Sciences, 2015
The African Flood Forecasting System (AFFS) is a probabilistic flood forecast system for medium- to large-scale African river basins, with lead times of up to 15 days.
V. Thiemig, B. Bisselink, F. Pappenberger, J. Thielen   +3 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Study on photovoltaic power forecasting model based on peak sunshine hours and sunshine duration

Energy Science & Engineering, 2023
Accurate prediction of photovoltaic power generation is a critical technical problem for utilizing solar energy. Aiming at the problem that the model parameters are difficult to obtain in applying photovoltaic power prediction methods, this paper has ...
Hang Zhao, Delan Zhu, Yalin Yang, Qianlin Li, Enze Zhang   +4 more
doaj   +1 more source

Remote Sensing-Supported Flood Forecasting of Urbanized Watersheds—A Case Study in Southern China

Remote Sensing, 2022
Urbanization has significant impacts on watershed hydrology, but previous studies have been confirmatory and not comprehensive; in particular, few studies have addressed the impact of urbanization on flooding in highly urbanized watersheds. In this study,
Yu Gu, Yangbo Chen, Huaizhang Sun, Jun Liu   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Load aggregation management strategies for demand response: a dual forecasting approach for cost minimization

Frontiers in Energy Research
The rising demand for electricity presents significant challenges to grid stability. Demand response programs address this issue by incentivizing consumers to adjust consumption during peak periods.
Pokpong Prakobkaew, Somporn Sirisumrannukul   +1 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source