Results 41 to 50 of about 477,957 (253)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

Numerical Study on Thermodynamic Coupling Characteristics of Fluid Sloshing in a Liquid Hydrogen Tank for Heavy-Duty Trucks

open access: yesEnergies, 2023
The large-amplitude sloshing behavior of liquid hydrogen in a tank for heavy-duty trucks may have adverse effects on the safety and stability of driving.
Yuhao Zhu   +5 more
doaj   +1 more source

Age influences magnitude but not duration of response to levodopa. [PDF]

open access: yesJournal of Neurology, Neurosurgery & Psychiatry, 1993
Following an all-night fast, 45 patients with Parkinson's disease were examined using certain motor items present in the United Parkinson's Disease Rating Scale. All were given a single tablet of carbidopa 25 mg and levodopa 250 mg and re-examined 90 minutes later.
R, Durso   +4 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Anaesthesia, not number of sessions, influences the magnitude and duration of an aHF-rTMS in dogs. [PDF]

open access: yesPLoS ONE, 2017
Currently, the rat has been a useful animal model in brain stimulation research. Nevertheless, extrapolating results from rodent repetitive Transcranial Magnetic Stimulation (rTMS) research to humans contains several hurdles.
Robrecht Dockx   +7 more
doaj   +1 more source

Nonreward confinement duration: The complement of reward magnitude [PDF]

open access: yesPsychonomic Science, 1965
Forty-eight rats were trained in the runway for 10 trials each day for 18 days under a 50% partial reinforcement schedule, confinement duration on the non-reinforced trials being either 10 sec. or 50 sec. Half of each group was extinguished under 10-sec. confinement (10-10, 50-10), half under 50-sec. (50-50, 10-50), there being seven days of extinction
E. J. Capaldi, Hugh B. Poynor
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Atrial time and voltage dispersion are both needed to predict new-onset atrial fibrillation in ischemic stroke patients

open access: yesBMC Cardiovascular Disorders, 2017
Background Atrial fibrillation (AF) is a known risk factor for ischemic stroke. Electrocardiographic predictors of AF in population studies such as the Framingham Heart Study, as well as in hypertensive patients have demonstrated a predictive value of ...
Daniel Cortez   +6 more
doaj   +1 more source

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