Results 61 to 70 of about 477,957 (253)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Soil microbial respiration adapts to higher and longer warming experiments at the global scale

Environmental Research Letters, 2023
Warming can affect soil microbial respiration by changing microbial biomass and community composition. The responses of soil microbial respiration to warming under experimental conditions are also related to background conditions and the experimental ...
Lu Yang, Junxiao Pan, Jinsong Wang, Dashuan Tian, Chunyu Zhang, Xiuhai Zhao, Jian Hu, Wen Yang, Yingjie Yan, Fangfang Ma, Weinan Chen, Quan Quan, Peiyan Wang, Shuli Niu   +13 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Land surface models systematically overestimate the intensity, duration and magnitude of seasonal-scale evaporative droughts

Environmental Research Letters, 2016
Land surface models (LSMs) must accurately simulate observed energy and water fluxes during droughts in order to provide reliable estimates of future water resources. We evaluated 8 different LSMs (14 model versions) for simulating evapotranspiration (ET)
A M Ukkola, M G De Kauwe, A J Pitman, M J Best, G Abramowitz, V Haverd, M Decker, N Haughton   +7 more
doaj   +1 more source

Effect of stimulus duration on vibrotactile sensation magnitude [PDF]

Bulletin of the Psychonomic Society, 1976
The method of magnitude estimation was used to determine the growth of vibrotactile sensation as a function of stimulus intensity at four burst durations. Measurements were made at a frequency of 250 Hz over the right thenar eminence of seven subjects. Results show that the resultant power functions grow slightly steeper as stimulus duration decreases ...
Ronald T. Verrillo, Robert L. Smith
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Monte Cristo Range earthquake May 15, 2020: calculated intensity and macroseismic field

Геология и геофизика Юга России, 2022
Relevance. When studying the seismic effect of the occurred earthquake, the collected macroseismic data are of great importance. To design the most reliable map of the macroseismic field, it’s necessary to have the sufficient number of such data, which ...
О.О. Эртелева, Ф.Ф. Аптикаев, К.С.К. Картик Редди, С. Чанда, С.Н. Сомала   +4 more
doaj  

The magnitude and duration of Clostridium difficile infection risk associated with antibiotic therapy: a hospital cohort study. [PDF]

PLoS ONE, 2014
Antibiotic therapy is the principal risk factor for Clostridium difficile infection (CDI), but little is known about how risks cumulate over the course of therapy and abate after cessation.
Kevin A Brown, David N Fisman, Rahim Moineddin, Nick Daneman   +3 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source