Results 101 to 110 of about 99,126 (309)

The great dust storm of 1986 [PDF]

It is reported that on the global scale, no major dust storm activity was seen during telescopic observations of Mars during the several months or so preceeding this conference.
James, P. B., Martin, L. J.
core   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

3D/Biela and the Andromedids: Fragmenting versus Sublimating Comets [PDF]

, 2007
Comet 3D/Biela broke up in 1842/1843 and continued to disintegrate in the returns of 1846 and 1852. When meteor storms were observed in November of 1872 and 1885, it was surmised that those showers were the debris from that breakup.
Jenniskens, P., Vaubaillon, J.
core   +2 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Analysis of the Effect of Climatic Parameters and Meteorological Droughts on the Variation of Internal Dust Events (A Case Study: Qazvin City)

علوم آب و خاک, 2020
The occurrence of wind erosion and the spread of dust particles can be regarded as one of the most important and threatening environmental factors. Climate change and the frequency of droughts have played an important role in exacerbating or weakening ...
S. Zandifar, Z. Ebrahimikhusfi, M. khosroshahi, M. Naeimi   +3 more
doaj  

Dominance of grain size impacts on seasonal snow albedo at deforested sites in New Hampshire [PDF]

, 2017
Snow cover serves as a major control on the surface energy budget in temperate regions due to its high reflectivity compared to underlying surfaces.
Aoki, Aoki, Aoki, Aoki, Banta, Barnett, Brown, Carmagnola, Cohen, Colbeck, Contosta, Dang, Delaney, Diamond, Doherty, Doherty, Douville, Draxler, Déry, Fierz, Flanner, Flanner, Fletcher, Gallet, Grenfell, Groisman, Hadley, Hall, Hallett, Hamilton, Hansen, Huntington, Intergovernmental Panel on Climate Change (IPCC), Kaspari, Kaspari, Knowles, Kokhanovsky, Lazarcik, Lhermitte, Libbrecht, Meinander, Nolin, Oaida, Painter, Painter, Painter, Painter, Painter, Pedersen, Peng, Perovich, Perovich, Picard, Polashenski, Qian, Qian, Qu, Qu, Ramanathan, Sall, Singh, Skiles, Skiles, Skiles, Slater, Steffensen, Sterle, Trenberth, Tukey, Verseghy, Warren, Weiss, White, Wiscombe, Wright, Yasunari   +75 more
core   +3 more sources

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source