Results 161 to 170 of about 178,753 (264)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Leadership and management competencies and practices among health managers in Wakiso District, Uganda. [PDF]

PLoS One
Musoke D, Ssembuusi A, Lubega GB, Niyongabo F, Brown MO, Holder R, Pitchford R, Gibson L.   +7 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Analysis of How the Term "Shall" Is Understood and Applied to the EU-HTA Regulation. [PDF]

J Mark Access Health Policy
Toumi M, Aballéa S, Fallissard B, Dussart C, Auquier P, Boyer L.   +5 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Facilitating return to work after major traumatic injuries through early vocational rehabilitation: Therapists' activities and perspectives. [PDF]

Aust Occup Ther J
Ross P, Mealings M, Analytis P, Hilton G, Barclay L, Fossey E, Downing M, Bedekar Y, Ponsford J.   +8 more
europepmc   +1 more source

Protecting belonging through anticipation: duty, duty, duty?

The Law Teacher
openaire   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Ipiq-Enlil and the Early Development of Veterinary Specialisation: Reassessing the Mari Letter from the Perspective of Veterinary History. [PDF]

Vet Sci
Małyszek A, Janeczek M.
europepmc   +1 more source