Results 181 to 190 of about 1,712,755 (309)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

The Regulation of the Holy Hospital Hagios Panteleimon: Administrative and Ethical Framework under the Ottoman Hegemony. [PDF]

Cureus
Kazazis C, Nikolakakis I, Tentolouris N, Psycharis I, Karamanou M.   +4 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

WHO's criteria for ethical health research priority-setting in the context of climate change. [PDF]

Bull World Health Organ
Pratt B, van der Graaf R, Samuel G.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Assessing workload, compensation, and burnout in academic dermatology: a national multi-institutional survey study. [PDF]

Int J Womens Dermatol
Brinks AL, Lawrence CN, Kearney CA, Maas D, Gillespie C, Adotama P, Senna M, Bordone L, Hordinsky M, Farah R, Aguh C, Mesinkovska N, Colavincenzo M, Mayo T, Krueger L, Elbuluk N, Okoye G, Strowd L, McMichael A, Goh C, Modanlo N, Lo Sicco KI.   +21 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

What predicts mucocutaneous exposure among health workers? Insights from an analytical cross-sectional study of 10 major hospitals in the Greater Accra region, Ghana. [PDF]

One Health
Tawiah PA, Appiah-Brempong E, Okyere P, Gyapong-Korsah B, Agyekum TP, Asumah PA, Boakye G, Buabeng-Odoom BE, Asiedu FO.   +8 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Return to Work Within 104 Weeks in Working-Age Patients Following Total Hip Arthroplasty. [PDF]

Cureus
Wouters NT, Wijnands KAP, Boonen B, Steijvers D, Most J, Gielen CLI, Schotanus MGM.   +6 more
europepmc   +1 more source