Results 141 to 150 of about 2,567,418 (399)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
2017 Anayasa Değişiklikleri Sonrası 1982 Anayasası’nda Yetki Ve Görev Olarak Yürütme
Yürütmenin Anayasa’nın 8. maddesi uyarınca bir görev olarak yerine getirilmesi, anayasa koyucunun doğrudan yürütme organına birtakım görevler vermesi şeklinde gerçekleşebilir.
Muhammed Göçgün
doaj +1 more source
DISCUSSION ON MODERN LOCOMOTIVES DESIGNED WITH A VIEW TO ECONOMY, DURABILITY AND FACILITY OF REPAIR; TOGETHER WITH SOME PARTICULARS OF THE DUTY PERFORMED, AND OF THE COST OF REPAIRS. [PDF]
James J. Robinson +22 more
openalex +1 more source
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
"Ethics of Duty and Values" is a jubilee book published on the occasion of the 40th anniversary of the scientific and teaching career of the distinguished philosopher Rev. Prof. Ryszard Moń.
Karolina Rozmarynowska
doaj +1 more source
Struggle Over Rights and Duties at Work: Storylines and Discursive Self-Other Positioning in Workplace Bullying Stories [PDF]
Pekka Kuusela +2 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Kur’anî Perspektiften Kant Ahlakı
Ahlak hem felsefenin hem de dinin ilgi alanındadır. Bu araştırmanın amacı, genelde felsefe açısından değil de, daha özelde Kant felsefesinde; ahlakın kaynağını ve yasasını istemeye (niyete) verilen değeri, buyrukların sınıflandırılışını, ayrıca bu ...
Murat Kayacan
doaj

