Results 181 to 190 of about 534,695 (315)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

[Report listing Homicide and Robbery Bureau officers and their duty status #1]

Report listing Homicide and Robbery Bureau officers and their duty status on November 22 ...
Dallas (Tex.). Police Department.
core  

Consensus Statement on Traumatic Brain Injury in First Responders: The 1st International Conference on TBI in First Responders. [PDF]

J Head Trauma Rehabil
Caccese JB, Oñate JA, Edwards N, Sas AR, Smith NIJ, Williams WH, Resch JE, Smith C, Schneider ALC, Hunzinger KJ, Akard C, August AM, Bailie JM, Barczak-Scarboro NE, Beach TJ, Boxley L, Bowman TG, Cameron KL, Cifu DX, Covassin T, Daugherty J, DePew C, D'Lauro CJ, Drew JM, Engle JR, Esopenko C, Funderburgh SF, Fong-Isariyawongse J, Guthrie MD, Hill J, Hoppes CW, Kirkland B, Kolacz J, Martin S, McKenna P, Nelson S, Nowrouzi-Kia B, Panchal AR, Popovich MJ, Register-Mihalik JK, Samuels S, Schmidt JD, Sprague M, Springer BL, Thrower MR, Walrod B, Walters J, Wilde EA, Willis J, Wing JJ, Wolfkiel R.   +50 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

[Report listing Homicide and Robbery Bureau officers and their duty status #2]

Report listing Homicide and Robbery Bureau officers and their duty status on November 22 ...
Dallas (Tex.). Police Department.
core  

Pandem-ethics: Post-mortem reflection on healthcare worker ethics during the time of coronavirus disease 2019 pandemonium. [PDF]

S Afr J Infect Dis
Bösenberg LH, Ueckermann V.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Predictors of Manipulation Under Anesthesia After Knee Arthroplasty in the United States Military Health System. [PDF]

Arthroplast Today
Smyth AM, Marshall IP, Lansford JL, McCarthy CF, Kinnard MJ, Slaven SE, Tracey RW.   +6 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Goal Programming Model for Nurse Shift Scheduling Incorporating Flexible Constraints: A Case Study in an Operating Room Department. [PDF]

Healthcare (Basel)
Demircioğlu M, Mutlu HE.
europepmc   +1 more source