Results 71 to 80 of about 2,567,418 (399)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Comply-and-Explain: Should Directors Have a Duty to Inform? [PDF]

, 2011
Wilcox discusses the compliance of the duty to inform of directors of publicly held companies. The expected long-term impact of a duty to inform would be to operationalize corporate governance policies and accustom boards to provide greater ...
Wilcox, John C.
core   +1 more source

Kant, Morality, and Hell [PDF]

, 2015
In this paper I argue that, although Kant argues that morality is independent of God (and hence, agrees with the Euthyphro), and rejects Divine Command Theory (or Theological Voluntarism), he believes that all moral duties are also the commands of God ...
GE Moore, I Kant, I Kant, I Kant, I Kant, I Kant, I Kant, J Austin, J Hall, J Rawls, L Denis, Plato, Plato, RG Swinburne, RJ Sullivan, S Darwall   +15 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Keynote Address, Regulating Corporate Governance in the Public Interest: The Case of Systemic Risk [PDF]

, 2015
There’s long been a debate whether corporate governance law should require some duty to the public. The accepted wisdom is not to require such a duty—that corporate profit maximization provides jobs and other public benefits that exceed any harm. This is
Schwarcz, Steven L.
core   +2 more sources

Study on Swirling Flow and Spray Characteristics of Central Stage Direct Injection Combustor

Energies
To investigate the physical phenomena interactions between airstream and liquid injection or droplets within a complex multi-stage swirl flow field, this study investigated the flow field and spray characteristics in a central stage direct injection ...
Wenjie Jiang, Ziyu Qi, Jinhu Yang, Deqing Mei, Kaixing Wang, Yushuai Liu, Shaolin Wang, Fuqiang Liu, Yong Mu, Cunxi Liu, Gang Xu   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cyberbullying - when does a school authority\u27s liability in tort end? [PDF]

, 2015
Cyberbullying in schools is increasing on an alarming rate. The development of the Internet and smartphone technology have increased the potential scope of a school authority’s duty of care for its students.
Francis, Tryon, Handal, Boris, Khalil, Jessica, Pelletier, Robert   +3 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Обов'язки подружжя, що виникають з приводу спільної сумісної власності

Проблеми Законності, 2016
У статті досліджуються обов’язки подружжя, що виникають з приводу спільної сумісної власності. Ааналізується питання можливості (неможливості) укладення правочинів одним із подружжя з приводу спільного майна без згоди іншого.
Вікторія Валентинівна Надьон
doaj   +1 more source