Results 71 to 80 of about 534,695 (315)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The control mechanisms of clearance ratio on squeeze film dampers performance

Scientific Reports
Rotating machinery is a crucial component in modern industrial systems, offering high efficiency and reliable performance. However, vibration issues significantly shorten their operational lifespan.
Zhongyu Yang, Jiaqi Li, Yihang Shi, Yinli Feng   +3 more
doaj   +1 more source

Regulation of the Labour relations in the first period of the Great Patriotic War

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2013
The questions of the changing standards in the USSR Labour Code during the War in 1922 are examined in the article. The more regular using of the labour duty, mobilization of the citizens into industrial and building works, the Legalization of overtime ...
Pishchulina Svetlana Yurievna
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Stamp duty on shares and its effect on share prices [PDF]

This paper provides a discussion of stamp duty and its effects. This is followed by an empirical study using changes in the rate of stamp duty in the UK as natural experiments.
Alexander Klemm, Steve Bond, Mike Hawkins   +2 more
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Study on Swirling Flow and Spray Characteristics of Central Stage Direct Injection Combustor

Energies
To investigate the physical phenomena interactions between airstream and liquid injection or droplets within a complex multi-stage swirl flow field, this study investigated the flow field and spray characteristics in a central stage direct injection ...
Wenjie Jiang, Ziyu Qi, Jinhu Yang, Deqing Mei, Kaixing Wang, Yushuai Liu, Shaolin Wang, Fuqiang Liu, Yong Mu, Cunxi Liu, Gang Xu   +10 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Economics of Duty-Free Shopping [PDF]

In 1999 the EU abolished duty-free on intra-EU travel, whilst other countries still retain duty-free shopping for international travellers. We address several aspects of duty-free trade, including effects on consumption, revenue and price-setting. From a
Vidar Christiansen, Stephen Smith
core