Results 51 to 60 of about 567,905 (318)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protecting Lives: A Quality Improvement Project to Improve Adherence to Fitness to Drive Policy in Mental Health Setting

BJPsych Open
Aims: Driving is a complex and rapidly evolving task that requires a high level of skill and the ability to simultaneously interact with both the vehicle and the external environment.
Sajid Mahmood, Tamara Chithiramohan, Omotilewa Omotoso, Waqqas Khokhar   +3 more
doaj   +1 more source

Willful Infringement and the Evidentiary Value of Opinion Letters After Knorr–Bremse v. Dana [PDF]

, 2005
Recently, the Federal Circuit in Knorr-Bremse v. Dana overruled almost twenty years of precedent by striking down the adverse inference doctrine, which had created a negative presumption against any alleged patent infringer for failing to obtain and ...
Stowell, Joshua
core   +1 more source

Balancing Autonomy Rights and Protection:Children’s Involvement in a Child Safety Online Project [PDF]

, 2011
Researchers who involve children in their research are faced with the challenge of choosing between differing theoretical approaches which can prioritise children’s autonomy rights or their ‘vulnerability’ and their need to be protected.
Alderson, Balen, Biggs, British Educational Research Association, British Sociological Association, Christensen, Cree, Department for Children, Schools and Families, Edwards, Flaskerud, Gallagher, Hagger, Harris, Heath, Holland, Hughes, Morrow, NCB, NCB, NSPCC, Ost, Royal College of Paediatrics, Child Health, Save the Children, Society for Research in Child Development, Walkerdine, Williamson   +25 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Navigating maritime law, law of the sea and human rights protection to inform climate adaptation

Global Constitutionalism
In ‘From survival cannibalism to climate politics: Rethinking Regina vs Dudley and Stephens’, Itamar Mann argues inter alia that survival cannibalism and the duty to rescue at sea can inform how to approach climate politics (Mann, p 1).
Ainhoa Campàs Velasco
doaj   +1 more source

Some Reflections on Consumer Protection and the Requirement of Anticipating Behaviour of A Prudent Insurer [PDF]

, 2013
__Abstract__ Insurers are increasingly reminded of the fact that they are the professionals in situations where the insured risks becoming the victim of the fact that he is a layperson, and may lose his insurance coverage unless the insurer takes ...
Frenk, N. (Niels), Wansink, J.H. (Han)
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source