Results 51 to 60 of about 89,910,502 (284)
Yixue yu zhexueThe inadequate protection of patients' informed consent rights is an important reason for the disharmony in doctor-patient relationship. Currently, Chinese law primarily focuses on protecting patients' passive right to be informed about medical ...
Qiheng LIU, Xiaoli TAN
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
BJPsych OpenAims: Driving is a complex and rapidly evolving task that requires a high level of skill and the ability to simultaneously interact with both the vehicle and the external environment.
Sajid Mahmood +3 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Surgeon's Duty to Warn of Risks
, 1984 The British and American approaches to the question of a surgeon's legal duty to warn of risks in surgical procedures are briefly outlined and commented upon, with the decisions ...
Wells, W.T.
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Navigating maritime law, law of the sea and human rights protection to inform climate adaptation
Global ConstitutionalismIn ‘From survival cannibalism to climate politics: Rethinking Regina vs Dudley and Stephens’, Itamar Mann argues inter alia that survival cannibalism and the duty to rescue at sea can inform how to approach climate politics (Mann, p 1).
Ainhoa Campàs Velasco
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Architect's continuing duty to review design [PDF]
, 2009 Architects are design professionals that are retained for their design expertise and an architect that enters into an agreement with the client has specific duties that he has to perform; he has a duty to exercise reasonable skill and care in carrying ...
Meor Adam, Arfah Hanum
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