Results 21 to 30 of about 3,790 (193)
Rapid Identification of DUX4::IGH Fusion in Acute Lymphoblastic Leukemia
eJHaemIntroduction DUX4 is rearranged and overexpressed in a subgroup of acute lymphoblastic leukemia (ALL) with B‐precursor phenotype, with a favorable outcome.
Kyoko Moritani +13 more
doaj +2 more sources
The FSHD atrophic myotube phenotype is caused by DUX4 expression. [PDF]
PLoS ONE, 2011 BACKGROUND:Facioscapulohumeral muscular dystrophy (FSHD) is linked to deletions in 4q35 within the D4Z4 repeat array in which we identified the double homeobox 4 (DUX4) gene.
Céline Vanderplanck +8 more
doaj +3 more sources
Estrogen interferes with DUX4 nuclear import
, 2023 DUX4 (Double Homeobox Protein 4) pathogenic activity is developed through transcriptional function and is associated with its nuclear localization. Three monopartite nuclear localization signals (NLS) are present in DUX4, but their function has not been ...
Fabiola Moretti +7 more
core +2 more sources
DUX4, the rockstar of embryonic genome activation?
The International Journal of Developmental BiologyDuring the initial days of development, the embryo gradually shifts from reliance on maternally provided RNAs and proteins to regulation of its own development. This transition is marked by embryonic genome activation (EGA).
Nykänen, Sonja, Vuoristo, Sanna
core +5 more sources
Current Opinion in Oncology, 2022 Purpose of review CIC-DUX4 sarcoma (CDS) is a high-grade undifferentiated round cells sarcoma that belongs to the undifferentiated round cell sarcomas family. It represents less than one percent of sarcomas, defining a rarest among rare malignancies. It affects young adults, displaying soft tissue mass.
Brahmi, Mehdi +4 more
openaire +3 more sources
Journal of Medical Sciences, 2022 CIC-DUX4 sarcoma is highly aggressive and rapidly develops lethal metastatic disease and chemoresistance. Its histology is similar to that of Ewing sarcoma and other small round cell sarcomas. Correlation with clinical data, radiological findings, pathological results (including immunohistochemistry and fluorescence in situ ...
Chang-Hung Liao +3 more
openaire +2 more sources
Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma [PDF]
Oncogenesis, 2021 AbstractCIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the transcriptional repressor Capicua (CIC) fused to the C-terminal transcriptional activation domain of DUX4.
Darko Bosnakovski +10 more
openaire +3 more sources
Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene. [PDF]
PLoS Genetics, 2010 Each unit of the D4Z4 macrosatellite repeat contains a retrotransposed gene encoding the DUX4 double-homeobox transcription factor. Facioscapulohumeral dystrophy (FSHD) is caused by deletion of a subset of the D4Z4 units in the subtelomeric region of ...
Lauren Snider +10 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2020 Facioscapulohumeral dystrophy (FSHD) is characterized by a loss of repressive epigenetic marks leading to the aberrant expression of the DUX4 transcription factor. In muscle, DUX4 acts as a poison protein though the induction of multiple downstream genes.
Virginie Mariot +5 more
doaj +1 more source
Nature Communications, 2021 Facioscapulohumeral muscular dystrophy is a myopathy caused by aberrant de-repression of the DUX4 gene. Here, the authors show that miR-675 inhibits DUX4 expression and protects muscles from DUX4-mediated cell death when administered to mice using AAV ...
Nizar Y. Saad +7 more
doaj +1 more source