Results 41 to 50 of about 21,870 (254)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Arterial Stiffness and Cardiorespiratory Fitness Impairment in the Community

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background During exercise, a healthy arterial system facilitates increased blood flow and distributes it effectively to essential organs. Accordingly, we sought to understand how arterial stiffening might impair cardiorespiratory fitness in community ...
Matthew Nayor, Priya Gajjar, Patricia Miller, Venkatesh L. Murthy, Ravi V. Shah, Nicholas E. Houstis, Raghava S. Velagaleti, Martin G. Larson, Ramachandran S. Vasan, Gregory D. Lewis, Gary F. Mitchell   +10 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Template matching to support earth observation based refugee camp analysis in obia workflows - creation and evaluation of a dwelling template library for improving dwelling extraction within an object-based framework [PDF]

GEOBIA 2016: Solutions and synergies, 2016
Accurate and reliable information about the situation in refugee or internally displaced person camps is very important for planning any kind of help like health care, infrastructure or vaccination campaigns. The number and spatial distribution of single dwellings extracted semi-automatically from very high resolution (VHR) satellite imagery as an ...
P. Krafft, D. Tiede, P. Füreder
openaire   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Psycho-social Needs of Community-dwelling Older Adults in Kerman, Southeast of Iran: A Qualitative Study [PDF]

Sālmand
Objectives Older adults have different needs and receive different supports. Community-dwelling older adults in Iran often do not receive organized psycho-social support. This study aimed to investigate the psycho-social needs of community-dwelling older
Monire Baloochi, Fardin Alipoor, Mohamad Sabzi Khoshnami, Payam Roshanfekr, Mohsen Shati   +4 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Lead Removal Without Extraction Tools: A Single-Center Experience

Brazilian Journal of Cardiovascular Surgery
Introduction: Indications for cardiac devices have been increasing as well as the need for lead extractions as a result of infections, failed leads and device recalls.
Neiberg de Alcantara Lima, Gisele Schinaider Cunha, Natalia Soares de Menezes, Evilásio Leobino da Silva Junior, Carol Cavalcante de Vasconcelos Lima, Stela Maria Vitorino Sampaio   +5 more
doaj   +1 more source

Psychosocial interventions for community-dwelling individuals with schizophrenia: study protocol for a systematic review and meta-analysis

BMJ Open, 2022
Introduction Despite the recent global mental health movement of the transition from hospital-centred to integrated community-based services, comprehensive evidence of psychosocial interventions focusing on community-dwelling individuals with ...
Hissei Imai, Aran Tajika, Naoki Yoshinaga, Hiroki Tanoue, Yasushi Ishida, Hideki Nakamura, Yoshifumi Kido, Yuki Shikuri, Fumitake Yamaguchi, Taichi Goto, Hirotake Sawada   +10 more
doaj   +1 more source