Results 171 to 180 of about 82,594 (297)

Genetically Proxied GIP‐GIPR Pathway Perturbation and Fracture Risk

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11839-11850, December 2026.
ABSTRACT Aims To determine whether genetic proxies for incretin pathway perturbation are associated with fracture risk and bone mineral density, providing human genetic evidence relevant to the skeletal safety of incretin‐based therapies. Materials and Methods We conducted drug‐target Mendelian randomisation using cis genetic variants near GIP, GIPR ...
Wenjie Cheng   +5 more
wiley   +1 more source

European Consortium for Lipodystrophies consensus definition and classification framework for monogenic lipodystrophy

open access: yesJournal of Internal Medicine, Volume 300, Issue 6, Page 725-742, December 2026.
Abstract Lipodystrophy comprises a heterogeneous group of disorders characterized by reduced adipose tissue often associated with severe metabolic complications. Lipodystrophy may be genetic, acquired, or secondary to medical therapies initiated for other conditions.
Robert K. Semple   +25 more
wiley   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

open access: yesArthritis Care &Research, Volume 78, Issue 11, Page 1741-1750, November 2026.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk   +7 more
wiley   +1 more source

Cognitive Performance in Young Adults During Three Consecutive Days of Simulated Occupational Heat Stress: An Exploratory Study

open access: yesAmerican Journal of Industrial Medicine, Volume 69, Issue 11, Page 931-947, November 2026.
ABSTRACT Introduction Global increases in occupational heat exposure are raising concerns about worker safety and cognitive performance during prolonged and repeated shifts. At present, the cumulative effects of repeated heat exposure on cognitive performance remain unclear.
Daniel C. Moore   +4 more
wiley   +1 more source

Assessment of Growth in Cardio‐Facio‐Cutaneous Syndrome

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2443-2453, November 2026.
ABSTRACT Cardio‐facio‐cutaneous (CFC) syndrome is a rare, multiple congenital anomaly disorder in which individuals commonly experience faltering growth; however, systematic analysis of growth parameters in this disorder has not been performed. We recruited 69 participants with CFC through CFC International and collected data on assessing height ...
Kari Johnston   +6 more
wiley   +1 more source

Which Anthropometric Index Best Signals 10‑Year Cardiovascular Risk? A Sex‑Stratified Analysis From the Shiraz Heart Study

open access: yesClinical Cardiology, Volume 49, Issue 11, November 2026.
In adults aged 40−70 years, body fat percentage, waist‐to‐height ratio, and waist‐to‐hip ratio were the strongest correlates of elevated 10‐year ASCVD risk, while fat‐free mass showed an inverse association. In younger adults, central adiposity and body fat measures were most strongly associated with higher ASCVD risk.
Mohammad Javad Zibaeenezhad   +16 more
wiley   +1 more source

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