Results 111 to 120 of about 7,254 (221)

Evolutionary diversification and characterization of the eubacterial gene family encoding DXR type II, an alternative isoprenoid biosynthetic enzyme

, 2021
Background: isoprenoids constitute a vast family of natural compounds performing diverse and essential functions in all domains of life. In most eubacteria, isoprenoids are synthesized through the methylerythritol 4-phosphate (MEP) pathway.
Albert, Victor A., Carretero-Paulet, Lorenzo, Rodríguez Concepción, Manuel, Lipska, Agnieszka, Pérez-Gil, Jordi, Sangari, Félix J.   +5 more
core  

UA enhanced the antitumoral effects of DXR in human STS cells while concomitantly down-regulating DXR-induced AKT phosphorylation and p21 protein levels.

, 2016
A) Synovial sarcoma SW982 (left) and leiomyosarcoma SK-UT-1 cells (right) were treated with vehicle (DMSO) or DXR (0.5, 1, 5 and 10 μM) alone or combined simultaneously with UA (10 μM for SW982 cells or 15 μM for SK-UT-1 cells) or TCN (30 μM) for 24 h ...
Regina Alemany (321441), Jordi Martínez-Serra (321436), Valentina Ruiz-Gutiérrez (2806483), Francisca Barceló (30107), Victor Hugo Villar (321434), Oliver Vögler (321435), Javier Martín-Broto (321440)   +6 more
core   +1 more source

Prototrophic DXR haploid deletion strains showed differential sensitivity to DOXO.

, 2013
Hypersensitivity demonstrated by DXR strains at (A) 75 µg/ml, (B) 165 µg/ml and (C) 310 µg/ml DOXO. Exponentially growing prototrophic strains were ten-fold serially diluted and individually spotted on DOXO-containing plates.
Kenichi Sajiki (276991), Ming Yi Tang (276993), Mitsuhiro Yanagida (214514), Ee Sin Chen (273621), Kim Kiat Lim (276992), Zoey Tay (276989), Ru Jun Eng (276990)   +6 more
core   +1 more source

Forskolin attenuates doxorubicin-induced cardiotoxicity by activating SIRT1/FOXO1/PINK1/Parkin-mediated mitophagy

Scientific African
Background: Despite the advancement of cancer therapy, chemotherapy is still a standard approach in cancer treatment. Doxorubicin (DXR) is a potent chemotherapeutic drug, used for the treatment of both adult and pediatric cancers.
Yomna S. Momen, Mohamed A. Kandeil, Mohamed O. Mahmoud   +2 more
doaj   +1 more source

Ray-Guided Volumetric Water Caustics in Single Scattering Media with DXR [PDF]

, 2019
This chapter presents a hybrid algorithm that uses ray tracing and rasterization to render surface and volumetric caustics in single scattering participating media. The algorithm makes use of ray tracing based on DirectX Raytracing (DXR) to generate data that drives hardware tessellation to adaptively refine triangular beam volumes that are rendered to
openaire   +1 more source

[[alternative]]MicroSPECT/CT Imaging and Pharmacokinetics of Re-188-(DXR)-liposome in Human Colorectal Adenocarcinoma-bearing Mice

, 2009
[[abstract]]Nanocarriers can selectively target cancer sites and carry payloads, thereby improving diagnostic and therapeutic effectiveness and reducing toxicity.
Chang, YJ;Chang, CH;Yu, CY;Chang, TJ;Chen, LC;Chen, MH;Lee, TW;Ting, G
core   +1 more source

Representative images of transgenerational phenotypes observed in offspring of DXR-treated (G0) females.

, 2013
(A) Examples of normal pups (day 0) born to CON females. (B) Physical malformations, particularly head abnormalities were observed in G4 pups (day 0), but note that only the G0 female was treated with DXR. (C) Representative karyotype of abnormal G4 pups,
Loro L. Kujjo (354585), Shilpa Dhar (354588), Ricardo J. G. Pereira (354587), Brenda Marrero-Rosado (354589), Eun A. Chang (354586), Satyaki Sengupta (249601), Gloria I. Perez (354590), Jose B. Cibelli (213200), Hongbing Wang (193024)   +8 more
core   +1 more source

Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits

International Journal of Medical Sciences, 2009
Purpose: Phlebitis caused by intravenous infusion of antineoplastic agents is one of the critical problems when anticancer therapy is prolonged. We have already reported that both rapid infusion and dilution of the injection solution were effective ...
Emiko Kohno, Saori Murase, Kenji Matsuyama, Noboru Okamura
doaj  

The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents

Molecules
It is established that reverse hydroxamate analogs of fosmidomycin inhibit the growth of Plasmodium falciparum by inhibiting 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate pathway, which is absent in humans.
Sana Takada, Mona A. Abdullaziz, Stefan Höfmann, Talea Knak, Shin-ichiro Ozawa, Yasumitsu Sakamoto, Thomas Kurz, Nobutada Tanaka   +7 more
doaj   +1 more source

Assessment of ovarian reserve after in vivo exposure to DXR.

, 2013
(A,B) DXR caused depletion of the primordial follicle pool in a time dependent manner ...
Loro L. Kujjo (354585), Shilpa Dhar (354588), Ricardo J. G. Pereira (354587), Brenda Marrero-Rosado (354589), Eun A. Chang (354586), Satyaki Sengupta (249601), Gloria I. Perez (354590), Jose B. Cibelli (213200), Hongbing Wang (193024)   +8 more
core   +1 more source