Results 151 to 160 of about 5,908 (179)

Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors

Bioorganic & Medicinal Chemistry, 2011
The diethyl esters and disodium salts of a range of heteroarylcarbamoylphosphonic acids have been prepared and evaluated as analogues of the highly active DOXP-reductoisomerase (DXR) inhibitor, fosmidomycin. Computer-simulated docking studies, Saturation Transfer Difference (STD) NMR analysis and enzyme inhibition assays have been used to explore ...
Bodill, Taryn, Conibear, Anne, Blatch, Gregory, Lobb, Kevin, Kaye, Perry T   +4 more
openaire   +5 more sources

±DXr Enklitiğinin Odaklayıcı İşlevi

Dil Araştırmaları
Bu makalede, Bütün adayı bir kuş cıvıltısıdır alır (FSKAB, 83), Bir patırdıdır gidiyor (SK II, 549), İşte bir kazadır oldu (K, 156), Yine bir gülmedir tutturdular (KT, 95) gibi cümlelerde kullanılan ve bir kiplik işaretleyicisi olarak ele aldığımız ±DXr enklitiğinin “odaklayıcılık” işlevi üzerinde durulmaktadır.
openaire   +2 more sources

DXR depresses the alpha-actinin-induced formation of actin bundles.

Cancer biochemistry biophysics, 1993
The filament-to-filament interactions in cardiac alpha-actinin/F-actin mixtures were investigated in the presence of doxorubicin. Stoichiometrical concentrations of the drug in the assembly medium inhibit the growth of alpha-actinin/F-actin three-dimensional structures, as shown by low speed centrifugation, light scattering, A320nm, electron microscopy
I. Dalle Donne, A. Milzani, R. Colombo
openaire   +2 more sources

Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations

Journal of Computer-Aided Molecular Design, 2007
Mycobacterium tuberculosis 1-deoxy-D: -xylulose-5-phosphate reductoisomerase (MtDXR) is a potential target for antitubercular chemotherapy. In the absence of its crystallographic structure, our aim was to develop a structural model of MtDXR. This will allow us to gain early insight into the structure and function of the enzyme and its likely binding to
Nidhi Singh 0002, Mitchell A. Avery, Christopher R. McCurdy   +2 more
openaire   +2 more sources

ON +DXr git- ~ tuttur- STRUCTURES

2017
Sınırlar arasılık, fiildeki hareketin başlangıç ve bitiş sınırları arasındaki bir noktasına, süreğine yönelen görünüş türüdür. Sınırlar arasılık görünüşü, bakış noktası bakımından, gerçekleşen fiilin ortasında olmasından dolayı genellikle eş zamanlı haber bildirimleri için karakteristiktir.
openaire   +1 more source

Non-hydroxamate inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR): A critical review and future perspective

European Journal of Medicinal Chemistry, 2021
Sandeep Sundriyal
exaly  

Screening for women with increased risk of fragility fractures in a general female population using digital X-ray radiogrammetry (DXR)

Maturitas, 2021
T B Brismar, B Freyschuss
exaly  

Hybridní raytracing v rozhraní DXR

The goal of this thesis is to evaluate the usability of hardware accelerated ray tracing in near-future rendering engines. Specifically, DirectX Ray Tracing API and Nvidia Turing architecture are being examined. Design and implementation of a hybrid rendering engine with support for hardware accelerated ray tracing is included and used in ...
openaire   +1 more source

DXR inhibitory activity of marine fungal methanolic fraction confers protection against vibriosis in Litopenaeus vannamei

Aquaculture, 2021
Jianming Chen
exaly  

Doxorubicin (DXR) modifies the density of specific atrial granules (SAGs) in dog heart

1987
Doxorubicin (DXR) modifies the density of specific atrial granules (SAGs) in dog ...
DANESI, ROMANO, Bellini O, BERNARDINI, NUNZIA, Del Tacca M.   +3 more
openaire   +3 more sources