Results 51 to 60 of about 848,056 (314)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Functionalization of black tea waste for application in bio-based natural rubber composites with enhanced properties

Industrial Crops and Products
The use of biowaste as fillers of polymers represents an important step toward creating sustainable composites with reduced environmental footprint. Therefore, the aim of the study was the functionalization of plant-based biofiller, one of the mainstream
Anna Sowińska-Baranowska, Aleksandra Juszkiewicz, Magdalena Maciejewska   +2 more
doaj   +1 more source

Extraction and Natural Cotton Dyeing of Valonia Oak and Anatolian Buckthorn by Microwave Irradiation

Journal of Natural Fibers, 2022
In this work, organic cotton fabrics were dyed using Rhamnus petiolaris Boiss, Quercus ithaburansis Decaisne, and Quercus ithaburansis Decaisne + Rhamnus petiolaris Boiss by microwave irradiation and conventional dyeing methods.
Recep Karadag, Banu Yesim Buyukakinci, Emine Torgan   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

In-situ microfluidic controlled low temperature hydrothermal growth of nanoflakes for dye-sensitized solar cells

, 2015
In this paper, an in-situ microfluidic control unit (MCU) was designed and applied in a hydrothermal synthesis process, which provides an easy way to localize liquid-phase reaction and realize selective synthesis and direct growth of nanostructures as ...
Child, David, Ping An, Hu, Robertson, Neil, Gibson, Desmond, Fu, Yong Qing, Hu, Yue, Zhao, Chao, Zhang, Jia   +7 more
core   +1 more source

Modeling Excited States and Alignment of Energy Levels in Dye-Sensitized Solar Cells: Successes, Failures, and Challenges [PDF]

, 2013
Theoretical and computational modeling is a powerful tool to investigate and characterize the structural, electronic, and optical properties of the main components of dye-sensitized solar cells (DSCs).
Pastore, Mariachiara, Fantacci, Simona, De Angelis, Filippo   +2 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Keratin-Integrated Latex–Hydrogel Coatings: Biopolymer Design for Functional Agrotextile Materials

Molecules
This work introduces a circular biopolymer-based strategy for valorizing keratin-rich industrial residues through the fabrication of biodegradable cotton agrotextiles functionalized with latex–hydrogel coatings.
Mirosława Prochoń, Szymon Szczepanik, Oleksandra Dzeikala, Robert Adamski   +3 more
doaj   +1 more source