Results 91 to 100 of about 741,154 (357)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Spectral barcode label for fighting illegal waste dumps [PDF]

open access: yes, 2010
Illegal waste dumping is one of the biggest problem in environment protection. Shipments of waste are left in wastelands, forests or dumped into the sea.
Diamond, Dermot   +2 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Surface modification of polyester using chicken feather keratin hydrolysate to improve water absorbency and dye uptake [PDF]

open access: yes, 2019
PET fiber has an intrinsic low hydrophilic character and an inactive surface which make it uncomfortable for wearing purpose. Moreover, it is difficult to colour polyester fabric other than disperse dyes.
Bayrau Nigusse, Abreha Bayrau   +4 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Dyeing of silk fabric with natural dyes extracted from cochineal (Dactylopius coccus Costa) and gall oak (Quercus infectoria Olivier)

open access: yesJournal of Natural Fibers, 2018
Silk fabric samples were mordanted with alum [KAl(SO4)2.12H2O]. Then, the samples were dyed with cochineal (Dactylopius coccus Costa) and gall oak (Quercus infectoria Olivier) shellac extracts. Optimum dyeing parameters were determined by using different
Burcu Yılmaz Şahinbaşkan   +2 more
doaj   +1 more source

Infrared tunable laser: A concept [PDF]

open access: yes, 1975
Apparatus in which laser wavelengths of two dyes are mixed in intracavity, nonlinear crystal provides intense source of coherent laser radiation which is tunable from visible through infrared wavelengths of electromagnetic ...
Billman, K. W.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

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