Results 111 to 120 of about 314,977 (308)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Who joins a UK right to die society and why? : a study of members of Friends at the End (FATE)
, 2012 PhDThe thesis presents quantitative and qualitative thematic analyses of a postal survey and interview study of members of Friends at the End (FATE), a Glasgow-based right to die society.
Judd, Marion Buchanan
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Radio broadcast regarding Bradford Dying Matters Week event
, 2017 Bradford Community Broadcasting (BCB). Live broadcast on 5th May and 10th May 2017 regarding publicity for University of Bradford Dying Matters Week ...
Buster, L.
core
Student nurses' attitudes towards death and dying in south-east Iran
, 2008 In this study, the attitudes of student nurses from Kerman and Bam in Iran towards death and caring for dying patients were compared. Two types of questionnaire were used: the DAP-R (Death Attitude Profile Revised) and FATCOD (Frommelt Attitude Towards ...
Iranmanesh, Sedigheh, +2 more
core +1 more source
Social SciencesIn recent years, research on older prisoners in England and Wales has expanded significantly, and the term “older prisoner” is now well entrenched in the prison-based literature.
Paul Gavin +2 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Fides et Ratio, 2018 Twenty-first century society believes in the almost infinite power of medicine, therefore in the mentality of modern man there is often no acceptance of serious illness or death.
Urszula Tataj-Puzyna +4 more
doaj