Results 71 to 80 of about 2,116,483 (268)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Design and implementation of CMUT multi-channel ultrasonic transceiver board based on PXIe

Dianzi Jishu Yingyong
To enable multi-channel pulse transmission, data acquisition, storage, transmission, and analysis based on a capacitive micromachined ultrasonic transducer (CMUT) array, a 32-channel ultrasound transceiver board was designed based on the PXIe bus.
Wu Shuaiqi, He Changde, Sun Shuaiwen, Lu Xiaoxing, Zhang Guojun, Zhang Wendong   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

From molecular dynamics to Brownian dynamics [PDF]

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2014
Three coarse-grained molecular dynamics (MD) models are investigated with the aim of developing and analysing multi-scale methods which use MD simulations in parts of the computational domain and (less detailed) Brownian dynamics (BD) simulations in the remainder of the domain. The first MD model is formulated in one spatial dimension.
openaire   +4 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Investigation of Submerged MEMS Ultrasonic Sensors for Underwater Obstacle Avoidance Application

Remote Sensing
Ultrasound is a powerful and versatile technology that has been applied extensively in medicine and scientific research. The development of miniature underwater robots focuses on achieving specific tasks, such as surveys and inspections in confined ...
Zhihao Wang, Wendong Zhang, Renxin Wang, Changde He, Shurui Liu, Jingwen Wang, Zhaodong Li, Xiaoxing Lu, Yun Qin, Guojun Zhang, Jiangong Cui, Yuhua Yang, Licheng Jia   +12 more
doaj   +1 more source

Study of Bio-Mimicry Surfaces for Optimization of Coupling Performance in Wheelchair Racing Gloves

Proceedings, 2018
In wheelchair racing, the optimal pair of gloves, as well as knowledge of conditioning of glove-rim contact surfaces can have a significant impact on race performance.
Clara Usma, Ned Volk, Damien Elderfield, Paul K. Collins   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Design and Algorithm Integration of High-Precision Adaptive Underwater Detection System Based on MEMS Vector Hydrophone

Micromachines
Real-time DOA (direction of arrival) estimation of surface or underwater targets is of great significance to the research of marine environment and national security protection.
Yan Liu, Boyuan Jing, Guojun Zhang, Jiayu Pei, Li Jia, Yanan Geng, Zhengyu Bai, Jie Zhang, Zimeng Guo, Jiangjiang Wang, Yuhao Huang, Lele Xu, Guochang Liu, Wendong Zhang   +13 more
doaj   +1 more source