Results 91 to 100 of about 24,634 (294)

Analysis of pogo on the space shuttle: Accumulator design guidelines and planar multiengine model development [PDF]

The design guidelines were generated to support the selection of the baseline accumulator configuration for the space shuttle. They were based upon the elimination of the instabilities that had been predicted for the shuttle system (in the absence of ...
Lock, M. H., Rubin, S.
core   +1 more source

The Legacy of the Tevatron in the Area of Accelerator Science

, 2013
For more than 25 years the Tevatron was the highest energy accelerator in the world, providing the first access to particle collisions beyond 1 TeV and achieving an ultimate performance a factor of four hundred beyond the original design goals.
Holmes, Stephen D., Shiltsev, Vladimir D.   +1 more
core   +1 more source

Potassium accumulation as dynamic modulator of neurohypophysial excitability

Neuroscience, 2010
Activity-dependent modulation of excitable responses from neurohypophysial axons and their secretory swellings has long been recognized as an important regulator of arginine vasopressin and oxytocin release during patterned stimulation. Various activity-dependent mechanisms, including action potential broadening, potassium accumulation, and autocrine ...
J, Foley, H, Nguyen, C B, Bennett, M, Muschol   +3 more
openaire   +3 more sources

Investigation of energy efficiency for electro-hydraulic composite braking system which is based on the regenerated energy

Advances in Mechanical Engineering, 2016
A novel structure of the combined braking system based on the regenerative braking energy has been proposed to achieve simplified structure and energy-saving capability simultaneously, which includes the hydraulic regenerative braking system, electro ...
Bin Ma, Muyi Lin, Yong Chen, Lian-xin Wang   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Design approach for a microprocessor-based GPS time transfer receiver [PDF]

, 1982
The design concept and characteristics of a self-contained microprocessor-based Global Positioning System time transfer receiver is described. A prototype of this unit is currently in the test phase. It employs two-bit digital baseband correlation rather
Ould, P. C., Vanwechel, R. J.
core   +1 more source

FPGA implementation of a 32x32 autocorrelator array for analysis of fast image series

, 2011
With the evolving technology in CMOS integration, new classes of 2D-imaging detectors have recently become available. In particular, single photon avalanche diode (SPAD) arrays allow detection of single photons at high acquisition rates (\geq 100 kfps ...
Balázs Kreith, Bestvater, Burkhardt, Capoulade, Colyer, Colyer, Culbertson, Edoardo Charbon, Engels, Greger, György Vámosi, Gábor Mocsár, Gösch, Hess, Heuvelman, Jan Buchholz, Jan Wolfgang Krieger, Jörg Langowski, Kannan, Kojro, Krichevsky, Laurence, Magatti, Magatti, Magde, Magde, Mocsar, Needleman, Niclass, Sankaran, Schaub, Schätzel, Schätzel, Tieman, Udo Kebschull, Wahl, Wocjan, Wohland   +37 more
core   +2 more sources

The effects of mergers with dynamic capacity accumulation [PDF]

International Journal of Industrial Organization, 2009
Abstract The U.S. antitrust law enforcement agencies often base their assessment of mergers on a model with asymmetric costs. However, in many near-homogeneous product industries there is evidence that cost differences are minor and capacity differences seem a more reasonable explanation of firm heterogeneity.
openaire   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dynamics of Lamin-A Processing Following Precursor Accumulation

PLoS ONE, 2010
Lamin A (LaA) is a component of the nuclear lamina, an intermediate filament meshwork that underlies the inner nuclear membrane (INM) of the nuclear envelope (NE). Newly synthesized prelamin A (PreA) undergoes extensive processing involving C-terminal farnesylation followed by proteolysis yielding non-farnesylated mature lamin A.
Qian Liu, Dae In Kim, Janet Syme, Phyllis LuValle, Brian Burke, Kyle J Roux   +5 more
openaire   +4 more sources