Results 71 to 80 of about 24,634 (294)

Firm Dynamics and Pricing Under Customer Capital Accumulation [PDF]

SSRN Electronic Journal, 2018
Abstract In a search model of firm dynamics, customer accumulation is shown to affect the lifecycle of firms and the dynamics of markups in response to aggregate demand shocks. In the model, sellers of different sizes and productivities post dynamic pricing contracts to strike a balance between attracting new customers and exploiting pre-existing ...
Pau Roldan-Blanco, Sonia Gilbukh
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Salience-based selection: attentional capture by distractors less salient than the target [PDF]

, 2013
Current accounts of attentional capture predict the most salient stimulus to be invariably selected first. However, existing salience and visual search models assume noise in the map computation or selection process.
A Found, A Kristjansson, A Soltani, A Treisman, AB Leber, AB Leber, Anja Isabel Koch, AR Koene, BA Purcell, C Hickey, C Hickey, C Koch, CL Folk, D Gao, D Gao, D Kahneman, DM Beck, G Schwarz, GW Humphreys, H Deubel, H-C Nothdurft, Harriet Goschy, HE Egeth, Hermann Joseph Müller, HJ Müller, HJ Müller, J de Fockert, J Hodsoll, J Palmer, J Palmer, J Theeuwes, J Theeuwes, J Theeuwes, J Vandekerckhove, JA Nelder, JH Reynolds, JI Gold, JM Wolfe, JM Wolfe, JM Wolfe, Joy J. Geng, JP Gottlieb, JP Gottlieb, JW Bisley, KR Cave, KR Cave, L Itti, L Itti, M Eimer, M Kiss, M Usher, M Usher, M Zehetleitner, M Zehetleitner, M Zehetleitner, M Zehetleitner, M Zehetleitner, M Zehetleitner, M Zehetleitner, M Zehetleitner, Michael Zehetleitner, MP Eckstein, N Lavie, NDB Bruce, P Verghese, P Verghese, R Desimone, R Desimone, R Ratcliff, R Ratcliff, RH Phaf, SJ Luck, T Töllner, T van Zandt, V Maljkovic, W van Zoest, W van Zoest, Z Li   +77 more
core   +4 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dynamic equations for nonassociated gas accumulation

Petroleum Exploration and Development, 2008
Nonassociated gas can be classified as conventional gas accumulation with displacement migration, source-contacting gas accumulation with piston-type migration, and shale gas accumulation with the displacement and piston-type migrations. Nonassociated gas accumulation can be described by using the continuous but universal dynamic equation.
Jin-chuan ZHANG, Xuan TANG, Rui-kang BIAN, Bo XU, Hui XUE, Hai-kuan NIE, Sheng-ling JIANG   +6 more
openaire   +2 more sources

Dynamic 3D Scene Analysis by Point Cloud Accumulation

, 2022
Multi-beam LiDAR sensors, as used on autonomous vehicles and mobile robots, acquire sequences of 3D range scans ("frames"). Each frame covers the scene sparsely, due to limited angular scanning resolution and occlusion. The sparsity restricts the performance of downstream processes like semantic segmentation or surface reconstruction. Luckily, when the
Huang, Shengyu, Gojcic, Zan, Huang, Jiahui, Wieser, Andreas, Schindler, Konrad   +4 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Power Matching and Energy Efficiency Improvement of Hydraulic Excavator Driven with Speed and Displacement Variable Power Source

Chinese Journal of Mechanical Engineering, 2019
Mobile machinery energy efficiency and emission pollution are the national and worldwide issues. This paper contributes in solving these problems by applying a speed variable power source.
Lei Ge, Long Quan, Xiaogang Zhang, Zhixin Dong, Jing Yang   +4 more
doaj   +1 more source