Results 211 to 220 of about 797,481 (300)

Structural and Dynamic Assessment of Disease-Causing Mutations for the Carnitine Transporter OCTN2. [PDF]

Mol Inform
Jokiel J, Bermudez M.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Influence of Computerized Dynamic Assessment on the Learning Potential of Graphical Analogical Reasoning in Children with Autism: Evidence from Eye-Movement Synchronization. [PDF]

Behav Sci (Basel)
Zhang K, Zhang Y, Chen J, Dai Y, Jin Y.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Dynamic Assessment of Fine Motor Control and Vocalization in Parkinson Disease Through a Smartphone App: Cross-Sectional Study of Time-Severity Interaction Effects. [PDF]

JMIR Mhealth Uhealth
Myong Y, Yun SJ, Park K, Oh BM, Seo HG.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS). [PDF]

J Biol Chem
Secic D, Bischoff ME, Schmidt L, Panmanee W, Yang J, Meller J, Vest KE, Cunningham JT, Landero JA, Czyzyk-Krzeska MF.   +9 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Author Correction: Spatiotemporal dynamic assessment and obstacle analysis of economic resilience in China's marine fisheries. [PDF]

Sci Rep
Qiao SY, Fan YP, Yin W.
europepmc   +1 more source