Results 111 to 120 of about 2,114,291 (335)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Comparison of Static and Dynamic Stability in Undergraduate Physiotherapy Student of Hyderabad And Jamshoro Sindh

open access: yesJournal Riphah College of Rehabilitation Sciences, 2019
Background: Basic daily activities include balance and coordination. Lack of balance can be a major risk factor of injuries related to daily activities. The classification of balance is static balance and dynamic balance.   Objectives: this report has
Bakhtawar Samejo   +2 more
doaj  

Investigation of Static and Dynamic Balance in School Basketball Players with a History of Ankle Injury

open access: yesBiyumikānīk-i varzishī, 2020
Objective: This study aimed to investigate the static and dynamic balance in basketball students with an ankle injury history. Methods: Subjects of this study were 36 elementary school basketball male students who participated in this study purposefully ...
Ali Roshandel Hesari   +1 more
doaj  

balanced allocation on dynamic hypergraphs

open access: yes, 2020
The {balls-into-bins model} randomly allocates $n$ sequential balls into $n$ bins, as follows: each ball selects a set $D$ of $d\ge 2$ bins, independently and uniformly at random, then the ball is allocated to a least-loaded bin from $D$ (ties broken randomly). The \emph{maximum load} is the maximum number of balls in any bin.
Greenhill, C, Mans, B, Pourmiri, A
openaire   +4 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause   +6 more
wiley   +1 more source

A validation of mobile sensing actigraphy devices for generating a biomechanical model of posture [PDF]

open access: yes, 2017
Mobile sensing actigraphy was tested and validated as a modality for computing dynamic posturography. Twelve healthy volunteer subjects (6 male) were administered risperidone and assessed for postural stability using a NeuroCom® Balance Master system and
Detheridge, Craig Neal
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

An Interpretable Machine Learning Framework for Athlete Motor Profiling Using Multi-Domain Field Assessments: A Proof-of-Concept Study

open access: yesApplied Sciences
Early detection of modifiable motor deficits is essential for safe, long-term athletic development, yet most field screens provide only binary risk scores.
Bartosz Wilczyński   +2 more
doaj   +1 more source

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